Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling
文献类型：期刊论文
| 作者 | Liu, Xiangyang1,5; Wang, Ye1,5; Liu, Feng1,5; Zhang, Min1,5; Song, Hejie1,5; Zhang, Zhen1,5; Zhou, Bin6; Lo, Cecilia W.4; Tong, Shilu3; Hu, Zhenlei2 |
| 刊名 | SCIENCE SIGNALING
 |
| 出版日期 | 2018 |
| 卷号 | 11期号:519页码:eaah5770 |
| ISSN号 | 1945-0877 |
| DOI | 10.1126/scisignal.aah5770 |
| 文献子类 | Article |
| 英文摘要 | During coronary vasculature development, endothelial cells enclose the embryonic heart to form the primitive coronary plexus. This structure is remodeled upon recruitment of epicardial cells that may undergo epithelial-mesenchymal transition (EMT) to enable migration and that give rise to smooth muscle cells. In mice expressing a loss-of-function mutant form of Wdpcp, a gene involved in ciliogenesis, the enclosure of the surface of the heart by the subepicardial coronary plexus was accelerated because of enhanced chemotactic responses to Shh. Coronary arteries, but not coronary veins in Wdpcp mutant mice, showed reduced smooth muscle cell coverage. In addition, Wdpcp mutant hearts had reduced expression of EMT and mesenchymal markers and had fewer epicardium-derived cells (EPDCs) that showed impaired migration. Epicardium-specific deletion of Wdpcp recapitulated the coronary artery defect of the Wdpcp mutant. Thus, Wdpcp promotes epithelial EMT and EPDC migration, processes that are required for remodeling of the coronary primitive plexus. The Wdpcp mutant mice will be a useful tool to dissect the molecular mechanisms that govern the remodeling of the primitive plexus during coronary development. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | SONIC-HEDGEHOG ; PRIMARY CILIUM ; SMOOTH-MUSCLE ; VASCULAR DEVELOPMENT ; SIGNALING PATHWAYS ; VESSEL DEVELOPMENT ; ENDOTHELIAL-CELLS ; POLARITY ; SEPTINS ; ORIGIN |
| 语种 | 英语 |
| WOS记录号 | WOS:000426208900001 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/736]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Pediat Translat Med Inst, Shanghai 200127, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Cardiovasc Surg, Shanghai 200011, Peoples R China, 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Clin Epidemiol & Biostat, Shanghai 200127, Peoples R China; 4.Univ Pittsburgh, Dept Dev Biol, Pittsburgh, PA 15201 USA; 5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai Pediat Congenital Heart Dis Inst, Shanghai 200127, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Xiangyang,Wang, Ye,Liu, Feng,et al. Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling[J]. SCIENCE SIGNALING,2018,11(519):eaah5770. |
| APA | Liu, Xiangyang.,Wang, Ye.,Liu, Feng.,Zhang, Min.,Song, Hejie.,...&,.(2018).Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling.SCIENCE SIGNALING,11(519),eaah5770. |
| MLA | Liu, Xiangyang,et al."Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling".SCIENCE SIGNALING 11.519(2018):eaah5770. |
入库方式： OAI收割
来源：上海营养与健康研究所
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