Transforming growth factor-beta 1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis
文献类型：期刊论文
| 作者 | Zhang, C-Y1,3; Yin, H-M1,3; Wang, H.1,3; Su, D.1,3; Xia, Y.1,3; Yan, L-F1,3; Fang, B.1,3; Liu, W.1,3; Wang, Y-M1,3; Zhou, Y.1,3 |
| 刊名 | LEUKEMIA
 |
| 出版日期 | 2018 |
| 卷号 | 32期号:2页码:479-491 |
| 关键词 | hypertension immunology inflammation regulatory T cell renin-angiotensin system complement |
| ISSN号 | 0887-6924 |
| DOI | 10.1038/leu.2017.198 |
| 文献子类 | Article |
| 英文摘要 | The understanding of hematopoietic stem cell (HSC) emergence is important to generate HSCs from pluripotent precursors. However, integrated signaling network that regulates the niche of nascent HSCs remains unclear. Herein, we uncovered a novel role of TGF-beta 1 in the metabolic niche of HSC emergence using the tgf-beta 1b(-/-) zebrafish. Our findings first showed that Tgf-beta 1 transcripts were enriched in the nascent HSCs. Loss of tgf-beta 1b caused a decrease of nascent HSCs within the aorta-gonad-mesonephros. Moreover, tgf-beta 1b(+) cells were runx1(+) HSCs and underwent an endothelial-to-hematopoietic-transition process. Although the autocrine of Tgf-beta 1 in HSCs rather than endothelial cells was highly demanded to regulate HSC generation, we found that tgf-beta 1b promoted HSC emergence through the endothelial c-Jun N-terminal kinase/c-Jun signaling. Chromatin immunoprecipitation (ChIP)-sequencing data showed that tgf-beta 1b/c-Jun targeted g6pc3 of FoxO signaling to promote gluconeogenesis and maintain a high glucose level in the niche. Furthermore, loss of tgf-beta 1b increased the endoplasmic-reticulum stress and oxidative stress by disturbing metabolic homeostasis. Adding a low dose of TGF-beta 1 protein could promote the differentiation of mouse embryonic stem cells towards HSCs in vitro. Altogether, our study provided insights into a new feature of TGF-beta 1 in the regulation of glucose metabolism and nascent HSC niche, which may contribute to therapies of hematological malignancies. |
| 学科主题 | Oncology ; Hematology |
| WOS关键词 | GROWTH-FACTOR-BETA ; FOXO TRANSCRIPTION FACTORS ; LEUKEMIA-INITIATING CELLS ; BONE-MARROW NICHE ; TGF-BETA ; TARGETED DISRUPTION ; AORTIC ENDOTHELIUM ; IN-VIVO ; HEMOGENIC ENDOTHELIUM ; METABOLIC-REGULATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000424517300025 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/738]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci, Shanghai, Peoples R China; 2.Nanjing Med Univ, Inst Toxicol, Sch Publ Hlth, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China, 3.Shanghai Jiao Tong Univ, Sch Med, Room 1618,Bldg A,320 Yue Yang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, C-Y,Yin, H-M,Wang, H.,et al. Transforming growth factor-beta 1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis[J]. LEUKEMIA,2018,32(2):479-491. |
| APA | Zhang, C-Y.,Yin, H-M.,Wang, H..,Su, D..,Xia, Y..,...&,.(2018).Transforming growth factor-beta 1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis.LEUKEMIA,32(2),479-491. |
| MLA | Zhang, C-Y,et al."Transforming growth factor-beta 1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis".LEUKEMIA 32.2(2018):479-491. |
入库方式： OAI收割
来源：上海营养与健康研究所
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