Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization
文献类型：期刊论文
| 作者 | Pan, Zhangyuan2,3; Liu, Qiuyue2; Zhou, Zhengkui2; Di, Ran2; Hu, Wenping2; Wang, Xiangyu2; He, Xiaoyun2; Guo, Xiaofei2; Liang, Benmeng2; Li, Xiaoyu2 |
| 刊名 | GIGASCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 7期号:4页码:- |
| ISSN号 | 2047-217X |
| 关键词 | domestic animal sheep adaptive evolution artificial selection semi-feralization horn |
| DOI | 10.1093/gigascience/giy019 |
| 文献子类 | Article |
| 英文摘要 | Background: Animal domestication has been extensively studied, but the process of feralization remains poorly understood. Results: Here, we performed whole-genome sequencing of 99 sheep and identified a primary genetic divergence between 2 heterogeneous populations in the Tibetan Plateau, including 1 semi-feral lineage. Selective sweep and candidate gene analysis revealed local adaptations of these sheep associated with sensory perception, muscle strength, eating habit, mating process, and aggressive behavior. In particular, a horn-related gene, RXFP2, showed signs of rapid evolution specifically in the semi-feral breeds. A unique haplotype and repressed horn-related tissue expression of RXFP2 were correlated with higher horn length, as well as spiral and horizontally extended horn shape. Conclusions: Semi-feralization has an extensive impact on diverse phenotypic traits of sheep. By acquiring features like those of their wild ancestors, semi-feral sheep were able to regain fitness while in frequent contact with wild surroundings and rare human interventions. This study provides a new insight into the evolution of domestic animals when human interventions are no longer dominant. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | HEARING-LOSS ; VESTIBULAR AQUEDUCT ; REVEALS ADAPTATION ; WIDE ASSOCIATION ; PENDRED-SYNDROME ; HIGH-ALTITUDE ; GENE ; DOMESTICATION ; POPULATION ; SELECTION |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000430067200001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/739]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Xinjiang Acad Anim Sci, Inst Anim Sci, Urumqi, Peoples R China; 2.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China; 3.Linyi Univ, Coll Agr & Forestry Sci, Linyi, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China; 5.Univ Chinese Acad Sci, Beijing, Peoples R China; 6.China Agr Univ, State Key Lab Agrobiotechnol, Beijing, Peoples R China; 7.BasePair BioTechonol Co Ltd, Suzhou, Peoples R China; 8.Xinjiang Acad Anim Sci, Inst Biotechnol, Urumqi, Peoples R China; 9.Tibet Acad Agr & Anim Husb Sci, Res Inst Anim Sci, Lhasa, Peoples R China; 10.Liaoning Normal Univ, Coll Life Sci, Dalian, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Pan, Zhangyuan,Liu, Qiuyue,Zhou, Zhengkui,et al. Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization[J]. GIGASCIENCE,2018,7(4):-. |
| APA | Pan, Zhangyuan.,Liu, Qiuyue.,Zhou, Zhengkui.,Di, Ran.,Hu, Wenping.,...&,.(2018).Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization.GIGASCIENCE,7(4),-. |
| MLA | Pan, Zhangyuan,et al."Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization".GIGASCIENCE 7.4(2018):-. |
入库方式： OAI收割
来源：上海营养与健康研究所
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