Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response
文献类型：期刊论文
| 作者 | Qi, Kai2; Li, Na2; Zhang, Zhenyu3; Melino, Gerry1; , |
| 刊名 | CELLULAR IMMUNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 326期号:-页码:86-93 |
| ISSN号 | 0008-8749 |
| 关键词 | Mesenchymal stem cells Immune responses |
| DOI | 10.1016/j.cellimm.2017.11.010 |
| 文献子类 | Article |
| 英文摘要 | Mesenchymal stem cells (MSCs) exist in almost all tissues with the capability to differentiate into several different cell types and hold great promise in tissue repairs in a cell replacement manner. The study of the bidirectional regulation between MSCs and immune response has ushered an age of rethinking of tissue regeneration in the process of stem cell-based tissue repairs. By sensing damaged signals, both endogenous and exogenous MSCs migrate to the damaged site where they involve in the reconstitution of the immune micro-environment and empower tissue stem/progenitor cells and other resident cells, whereby facilitate tissue repairs. This MSC-based therapeutic manner is conferred as cell empowerment. In this process, MSCs have been found to exert extensive immunosuppression on both innate and adaptive immune response, while such regulation needs to be licensed by inflammation. More importantly, the immunoregulation of MSCs is highly plastic, especially in the context of pathological microenvironment. Understanding the immunoregulatory properties of MSCs is necessary for appropriate application of MSCs. Here we review the current studies on the crosstalk of MSCs and immune response in disease pathogenesis and therapy. |
| 学科主题 | Cell Biology ; Immunology |
| WOS关键词 | REGULATORY T-CELLS ; VERSUS-HOST-DISEASE ; MARROW STROMAL CELLS ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; NATURAL-KILLER-CELLS ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; GROWTH-FACTOR-BETA ; BONE-MARROW ; DENDRITIC CELLS ; MEDIATED IMMUNOSUPPRESSION |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000429750000012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/740]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Roma Tor Vergata, Dept Expt Med & Surg, Bldg D,Room D26,2 Floor,Via Montpellier 1, I-00133 Rome, Italy, 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.Qihe Ctr Dis Control & Prevent, Qihe Cty 251100, Shandong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Qi, Kai,Li, Na,Zhang, Zhenyu,et al. Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response[J]. CELLULAR IMMUNOLOGY,2018,326(-):86-93. |
| APA | Qi, Kai,Li, Na,Zhang, Zhenyu,Melino, Gerry,&,.(2018).Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response.CELLULAR IMMUNOLOGY,326(-),86-93. |
| MLA | Qi, Kai,et al."Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response".CELLULAR IMMUNOLOGY 326.-(2018):86-93. |
入库方式： OAI收割
来源：上海营养与健康研究所
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