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The Development and Regeneration of Coronary Arteries

文献类型：期刊论文

作者He, Lingjuan2,3; Zhou, Bin2,3; Zhou, Bin1,4; ,
刊名CURRENT CARDIOLOGY REPORTS
出版日期2018
卷号20期号:7页码:54
关键词Coronary artery Cellular origins Genetic lineage tracing Coronary heart disease
ISSN号1523-3782
DOI10.1007/s11886-018-0999-2
文献子类Review
英文摘要Purpose of Review In this review, we aim to summarize and discuss the cellular origins of the coronary endothelial cells during development and neovascularization in the adult stage after cardiac injury. Recent findings Recent work identified three different developmental origins for coronary endothelial cells: proepicardium, endocardium, and sinus venosus. However, the level of contribution by each source remains debated. During heart injury and regeneration, although multiple cell types such as endothelial progenitor cells, epicardial cells, and endocardial cells were reported to contribute neovascularization, convincing evidence is still lacking.. Recently, fibroblasts were reported to contribute to endothelial cells after cardiac injury through mesenchymal-to-endothelial transition. A subsequent study demonstrated that pre-existing endothelial cells mainly mediate cardiac neovascularization after injury. Summary The developmental origins of coronary vessels are diverse and further studies are needed to address the exact contribution from each source and the molecular mechanism governing distinct vessel formation programs. In the adult stage, neovascularization is mainly mediated by the pre-existing endothelial cells, with negligible contribution from other sources.
学科主题Cardiovascular System & Cardiology
WOS关键词ENDOTHELIAL PROGENITOR CELLS ; CARDIAC NEOVASCULARIZATION ; DEFINED FACTORS ; ADULT HEART ; ANGIOGENESIS ; FIBROBLASTS ; MYOCARDIUM ; LINEAGE ; CARDIOMYOCYTES ; CONTRIBUTES
语种英语
WOS记录号WOS:000433260900003
出版者SPRINGER
版本出版稿
源URL[http://202.127.25.144/handle/331004/741]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Jinan Univ, Inst Aging & Regenerat Med, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Guangdong, Peoples R China,
2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai 200031, Peoples R China;
3.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China;
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
推荐引用方式
GB/T 7714		 He, Lingjuan,Zhou, Bin,Zhou, Bin,et al. The Development and Regeneration of Coronary Arteries[J]. CURRENT CARDIOLOGY REPORTS,2018,20(7):54.
APA He, Lingjuan,Zhou, Bin,Zhou, Bin,&,.(2018).The Development and Regeneration of Coronary Arteries.CURRENT CARDIOLOGY REPORTS,20(7),54.
MLA He, Lingjuan,et al."The Development and Regeneration of Coronary Arteries".CURRENT CARDIOLOGY REPORTS 20.7(2018):54.

入库方式： OAI收割

来源：上海营养与健康研究所

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