中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海营养与健康研究所
  3. 中国科学院上海生命科学研究院营养科学研究所
Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid

文献类型：期刊论文

作者Li, Shengdi1,2,3; Chang, Ziyi2; Zhu, Tianqing2; Villacorta, Luis2; Chen, Y. Eugene2; Zhang, Jifeng2; Li, Yixue3; Freeman, Bruce A.4; ,
刊名PHYSIOLOGICAL GENOMICS
出版日期2018
卷号50期号:4页码:287-295
ISSN号1094-8341
关键词conjugated linoleic acid nitro-fatty acid nitroalkene RNA-Seq vascular smooth muscle cell
DOI10.1152/physiolgenomics.00090.2017
文献子类Article
英文摘要Nitro-conjugated linoleic acid (NO2-CLA) is formed by metabolic and inflammatory reactions of nitric oxide and nitrite, and represents the most abundant nitro-fatty acid species in humans. These electrophilic fatty acid nitroalkene derivatives mediate pleiotropic cell signaling responses. Here, we report a systematic approach to investigate the effect of NO2-CLA on human coronary artery smooth muscle cells (hCASMC), based on the RNA-Seq and bioinformatics analysis. There were extensive differentially expressed genes in NO2-CLA vs. control (510) and NO2-CLA vs. CLA (272) treatment groups, respectively. Notably, only minimal alterations were observed in CLA vs. control conditions, indicating that the electrophilic character of NO2 CLA is requited to induce differential gene expression responses independently from native CLA. Functional enrichment analysis of differentially expressed genes reveals multiple cellular processes to be affected under NO2-CLA treatment, including cell proliferation, lipid metabolism, antioxidant and inflammatory-related gene expression responses. These findings reveal that nitro-fatty acid derivatives such as NO2-CLA regulate a broad array of adaptive gene expression responses by hCASMC.
学科主题Cell Biology ; Genetics & Heredity ; Physiology
WOS关键词HEME OXYGENASE-1 EXPRESSION ; OXIDIZED LIPID DERIVATIVES ; NITRATED FATTY-ACIDS ; ANGIOPOIETIN-LIKE 4 ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; RNA-SEQ ; TRANSDUCTION ; INFLAMMATION ; ACTIVATION
语种英语
出版者AMER PHYSIOLOGICAL SOC
WOS记录号WOS:000440969300007
版本出版稿
源URL[http://202.127.25.144/handle/331004/742]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China;
2.Univ Michigan, Frankel Cardiovasc Ctr, Dept Internal Med, Med Ctr, Ann Arbor, MI 48109 USA;
3.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Key Lab Computat Biol, Shanghai, Peoples R China;
4.Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA,
推荐引用方式
GB/T 7714		 Li, Shengdi,Chang, Ziyi,Zhu, Tianqing,et al. Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid[J]. PHYSIOLOGICAL GENOMICS,2018,50(4):287-295.
APA Li, Shengdi.,Chang, Ziyi.,Zhu, Tianqing.,Villacorta, Luis.,Chen, Y. Eugene.,...&,.(2018).Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid.PHYSIOLOGICAL GENOMICS,50(4),287-295.
MLA Li, Shengdi,et al."Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid".PHYSIOLOGICAL GENOMICS 50.4(2018):287-295.

入库方式： OAI收割

来源：上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。