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Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1

文献类型：期刊论文

作者Wang, Yan1,2,4; Yuan, Jia1,2,4; Dai, Dongfang1,2,4; Liu, Junli1,2,4; Xu, Jing1,2,4; Miao, Xiang1,2,4; Mao, Chaoming1,2,4; Xiao, Yichuan1,2,4; Wang, Huan3; ,
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期2018
卷号50期号:9页码:862-868
关键词poly IC B cell systemic lupus erythematosus Peli1 noncanonical NF-kappa B
ISSN号1672-9145
DOI10.1093/abbs/gmy082
文献子类Article
英文摘要Noncanonical NF-kappa B pathway is essential for the B cell activation and antibody production, which centralize the critical role of B cells in regulating the pathogenesis of systemic lupus erythematosus (SLE). We have previously demonstrated that Pellinol (Peli1) negatively regulates noncanonical NF-kappa B activation and lupus autoimmunity. Here, we showed that poly IC is a potent inducer of Peli1 protein in mouse splenic B cells in dose- and time-dependent manners, and poly IC-induced Peli1 protein dramatically suppressed the activation of noncanonical NF-kappa B pathway. In addition, poly IC-pretreated B cells failed to induce lupus-like disease in BM12 CD4(+) T cell-immunized mice. Accordingly, the induction of antibody-producing plasma cells and germinal center B cells, as well as the production of autoantibodies were significantly impaired in immunized mu MT mice that were transferred with poly IC-pretreated B cells. Our findings demonstrate that poly IC-induced Peli1 negatively regulates the noncanonical NF-kappa B pathway in the context of restraining the pathogenesis of lupus-like disease.
学科主题Biochemistry & Molecular Biology ; Biophysics
WOS关键词NF-KAPPA-B ; DOUBLE-STRANDED-RNA ; ERYTHEMATOSUS ; OVEREXPRESSION ; ACTIVATION ; BAFF ; TLR ; PATHOGENESIS ; RESPONSES ; SYSTEM
语种英语
WOS记录号WOS:000443538800004
出版者OXFORD UNIV PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/746]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
2.Jiangsu Univ, Dept Nucl Med, Affiliated Hosp, Zhenjiang 212001, Peoples R China;
3.Hebei Med Univ, Sch Pharm, Shijiazhuang 050017, Hebei, Peoples R China,
4.Shanghai Jiao Tong Univ, Sch Med, Inst Hlth Sci, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Wang, Yan,Yuan, Jia,Dai, Dongfang,et al. Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50(9):862-868.
APA Wang, Yan.,Yuan, Jia.,Dai, Dongfang.,Liu, Junli.,Xu, Jing.,...&,.(2018).Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50(9),862-868.
MLA Wang, Yan,et al."Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50.9(2018):862-868.

入库方式： OAI收割

来源：上海营养与健康研究所

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