Associations of plasma very-long-chain SFA and the metabolic syndrome in adults
文献类型：期刊论文
| 作者 | Zhao, Jing4; Li, Xiaofan4; Li, Xiang4; Chu, Qianqian4; Li, Zi4; Gao, Ying4; Zhou, Yunhua5; Zhang, Hong6; Brenna, Thomas J.1,2; Song, Yiqing3 |
| 刊名 | BRITISH JOURNAL OF NUTRITION
 |
| 出版日期 | 2018 |
| 卷号 | 120期号:8页码:855-862 |
| 关键词 | Cross-sectional studies Hypertriacylglycerolaemia Metabolic syndrome SFA Follow-up studies |
| ISSN号 | 0007-1145 |
| DOI | 10.1017/S0007114518002106 |
| 文献子类 | Article |
| 英文摘要 | Plasma levels of very-long-chain SFA (VLCSFA) are associated with the metabolic syndrome (MetS). However, the associations may vary by different biological activities of individual VLCSFA or population characteristics. We aimed to examine the associations of VLCSFA and MetS risk in Chinese adults. Totally, 2008 Chinese population aged 35-59 years were recruited and followed up from 2010 to 2012. Baseline MetS status and plasma fatty acids data were available for 1729 individuals without serious diseases. Among 899 initially metabolically healthy individuals, we identified 212 incident MetS during the follow-up. Logistic regression analysis was used to estimate OR and 95 % CI. Cross-sectionally, each VLCSFA was inversely associated with MetS risk; comparing with the lowest quartile, the multivariate-adjusted OR for the highest quartile were 0.18 (95 % CI 0.13, 0.25) for C20 : 0, 0.26 (95 % CI 0.18, 0.35) for C22 : 0, 0.19 (95 % CI 0.13, 0.26) for C24 : 0 and 0.16 (0.11, 0.22) for total VLCSFA (all P-for trend<0001). The associations remained significant after further adjusting for C16 : 0, C18 : 0, C18 : 3n-3, C22 : 6n-3, n-6 PUFA and MUFA, respectively. Based on follow-up data, C20 : 0 or C22 : 0 was also inversely associated with incident MetS risk. Among the five individual MetS components, higher levels of VLCSFA were most strongly inversely associated with elevated TAG (>= 1.7 mmol/l). Plasma levels of VLCSFA were significantly and inversely associated with MetS risk and individual MetS components, especially TAG. Further studies are warranted to confirm the findings and explore underlying mechanisms. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | SATURATED FATTY-ACIDS ; CARDIOVASCULAR-DISEASE ; INSULIN-RESISTANCE ; OLDER-ADULTS ; RISK ; CERAMIDES ; WOMEN ; HEALTH ; CONSUMPTION ; POPULATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000445852400002 |
| 出版者 | CAMBRIDGE UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/747]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Texas Austin, Dell Pediat Res Inst, Dell Med Sch, Austin, TX 78705 USA; 2.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA; 3.Indiana Univ, Dept Epidemiol, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46202 USA, 4.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China; 5.Fudan Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Shanghai 200032, Peoples R China; 6.Fudan Univ, Inst Biostat, Shanghai 200433, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Jing,Li, Xiaofan,Li, Xiang,et al. Associations of plasma very-long-chain SFA and the metabolic syndrome in adults[J]. BRITISH JOURNAL OF NUTRITION,2018,120(8):855-862. |
| APA | Zhao, Jing.,Li, Xiaofan.,Li, Xiang.,Chu, Qianqian.,Li, Zi.,...&,.(2018).Associations of plasma very-long-chain SFA and the metabolic syndrome in adults.BRITISH JOURNAL OF NUTRITION,120(8),855-862. |
| MLA | Zhao, Jing,et al."Associations of plasma very-long-chain SFA and the metabolic syndrome in adults".BRITISH JOURNAL OF NUTRITION 120.8(2018):855-862. |
入库方式： OAI收割
来源：上海营养与健康研究所
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