Aging and Alzheimer's disease: Comparison and associations from molecular to system level
文献类型：期刊论文
| 作者 | Xia, Xian; Jiang, Quanlong; McDermott, Joseph; Han, Jing-Dong J.; , |
| 刊名 | AGING CELL
 |
| 出版日期 | 2018 |
| 卷号 | 17期号:5页码:UNSP e12802 |
| 关键词 | aging Alzheimer's disease cell type composition comparison and association epigenetics genetic susceptibility microglia system inflammation |
| ISSN号 | 1474-9726 |
| DOI | 10.1111/acel.12802 |
| 文献子类 | Review |
| 英文摘要 | Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa. |
| 学科主题 | Cell Biology ; Geriatrics & Gerontology |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; AMYLOID-BETA-PEPTIDE ; LONG NONCODING RNAS ; APOLIPOPROTEIN-E GENOTYPE ; BRAIN INSULIN-RESISTANCE ; GROWTH-FACTOR EXPRESSION ; NEURAL STEM-CELLS ; SLEEP-WAKE CYCLE ; GUT MICROBIOTA ; MOUSE MODEL |
| 语种 | 英语 |
| WOS记录号 | WOS:000445599100004 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/748]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Univ Chinese Acad Sci, Chinese Acad Sci,CAS Key Lab Computational Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, CAS MPG Partner Inst Computat Biol,Shanghai Inst, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xia, Xian,Jiang, Quanlong,McDermott, Joseph,et al. Aging and Alzheimer's disease: Comparison and associations from molecular to system level[J]. AGING CELL,2018,17(5):UNSP e12802. |
| APA | Xia, Xian,Jiang, Quanlong,McDermott, Joseph,Han, Jing-Dong J.,&,.(2018).Aging and Alzheimer's disease: Comparison and associations from molecular to system level.AGING CELL,17(5),UNSP e12802. |
| MLA | Xia, Xian,et al."Aging and Alzheimer's disease: Comparison and associations from molecular to system level".AGING CELL 17.5(2018):UNSP e12802. |
入库方式： OAI收割
来源：上海营养与健康研究所
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