Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and stress-responsive activities
文献类型：期刊论文
| 作者 | Liu, Lanlan2,3; Wang, Haiwei2; Liu, Jiansheng1,4; Du, Yanzhi1,4; Zhao, Hui5; , |
| 刊名 | ONCOLOGY LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:4页码:5339-5348 |
| 关键词 | cancer stem cells sphere colon cancer fenretinide cell cycle cell stress |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol.2018.9296 |
| 文献子类 | Article |
| 英文摘要 | Cancer stem cells (CSCs) are considered to be the main cause of chemoresistance and the resultant low survival rate of patients with cancer. N-(4-hydroxyphenyl)-retinamide, known as fenretinide or 4HPR, is a synthetic derivative of all-trans-retinoic acid. It is a promising anticancer agent, has minimal side effects and synergizes with other anticancer agents to reinforce their anticancer efficacy. The present study investigated whether fenretinide eliminated colon sphere cells. HT29 and HCT116 cells incubated in low-serum culture medium were more sensitive to fenretinide treatment than those incubated in full-serum medium. Colon spheres formed in serum-free medium demonstrated stem-like characteristics. The percentage of cluster of differentiation (CD) 44(+) cells was significantly higher in sphere cells compared with parental cells. Sphere cells also demonstrated increased tumorigenic ability in non-obese diabetic/severe combined immunodeficiency mice. Fenretinide inhibited the formation of colon spheres in HT29 and HCT116 cells. Microarray, cell cycle and reverse transcription-quantitative polymerase chain reaction analysis revealed that fenretinide induced genes associated with cell cycle regulation and the stress response in fenretinide-treated HT29 sphere cells. To the best of our knowledge, the present study was the first to investigate the effect of fenretinide on colon stem cells. Fenretinide was demonstrated to preferentially target colon sphere cells, which may possess certain stem-like characteristics. These results are an important addition to the current knowledge concerning fenretinide, and provide a foundation for its clinical application in the treatment of cancer. |
| 学科主题 | Oncology |
| WOS关键词 | CHRONIC MYELOID-LEUKEMIA ; STEM-CELLS ; STEM/PROGENITOR CELLS ; INDUCED APOPTOSIS ; INITIATING CELLS ; GENE-EXPRESSION ; HYBRIDIZATION ; MECHANISMS ; INDUCTION ; DRUG |
| 语种 | 英语 |
| WOS记录号 | WOS:000444990700159 |
| 出版者 | SPANDIDOS PUBL LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/750]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai 200135, Peoples R China; 2.SJTUSM, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Ctr Reprod Med, 845 Lingshan Rd, Shanghai 200135, Peoples R China; 5.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong 999077, Hong Kong, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Lanlan,Wang, Haiwei,Liu, Jiansheng,et al. Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and stress-responsive activities[J]. ONCOLOGY LETTERS,2018,16(4):5339-5348. |
| APA | Liu, Lanlan,Wang, Haiwei,Liu, Jiansheng,Du, Yanzhi,Zhao, Hui,&,.(2018).Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and stress-responsive activities.ONCOLOGY LETTERS,16(4),5339-5348. |
| MLA | Liu, Lanlan,et al."Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and stress-responsive activities".ONCOLOGY LETTERS 16.4(2018):5339-5348. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。