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Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer

文献类型：期刊论文

作者Zhang, Tian-Ming2; Huang, Tao3; Wang, Rong-Fei1; ,
刊名ONCOLOGY LETTERS
出版日期2018
卷号16期号:2页码:1736-1746
关键词chromosome instability CpG island methylator phenotype mismatch repair minimal redundancy maximal relevance incremental feature selection random walk with restart
ISSN号1792-1074
DOI10.3892/ol.2018.8860
文献子类Article
英文摘要Colorectal cancer is a severe cancer associated with a high prevalence and fatality rate. There are three major mechanisms for colorectal cancer: (1) Chromosome instability (CIN), (2) CpG island methylator phenotype (CIMP) and (3) mismatch repair (MMR), of which CIN is the most common type. However, these subtypes are not exclusive and overlap. To investigate their biological mechanisms and cross talk, the gene expression profiles of 585 colorectal cancer patients with CIN, CIMP and MMR status records were collected. By comparing the CIN+ and CIN-samples, CIMP+ and CIMP-samples, MMR+ and MMR-samples with minimal redundancy maximal relevance (mRMR) and incremental feature selection (IFS) methods, the CIN, CIMP and MMR associated genes were selected. Unfortunately, there was little direct overlap among them. To investigate their indirect interactions, downstream genes of CIN, CIMP and MMR were identified using the random walk with restart (RWR) method and a greater overlap of downstream genes was indicated. The common downstream genes were involved in biosynthetic and metabolic pathways. These findings were consistent with the clinical observation of wide range metabolite aberrations in colorectal cancer. To conclude, the present study gave a gene level explanation of CIN, CIMP and MMR, but also showed the network level cross talk of CIN, CIMP and MMR. The common genes of CIN, CIMP and MMR may be useful for cross-subtype general colorectal cancer drug development.
学科主题Oncology
WOS关键词PROTEIN-INTERACTION NETWORKS ; COPY NUMBER VARIATION ; FEATURE-SELECTION ; COMPUTATIONAL METHOD ; COLON ; CLASSIFICATION ; REDUNDANCY ; PREDICTION ; MUTATIONS ; RELEVANCE
语种英语
WOS记录号WOS:000444763100049
出版者SPANDIDOS PUBL LTD
版本出版稿
源URL[http://202.127.25.144/handle/331004/753]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Jinhua Peoples Hosp, Dept Colorectal & Anal Surg, 228 Xinhua St, Jinhua 321000, Zhejiang, Peoples R China,
2.Zhejiang Univ, Dept Colorectal & Anal Surg, Jinhua Hosp, Jinhua 321000, Zhejiang, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Tian-Ming,Huang, Tao,Wang, Rong-Fei,et al. Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer[J]. ONCOLOGY LETTERS,2018,16(2):1736-1746.
APA Zhang, Tian-Ming,Huang, Tao,Wang, Rong-Fei,&,.(2018).Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer.ONCOLOGY LETTERS,16(2),1736-1746.
MLA Zhang, Tian-Ming,et al."Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer".ONCOLOGY LETTERS 16.2(2018):1736-1746.

入库方式： OAI收割

来源：上海营养与健康研究所

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