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Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge

文献类型：期刊论文

作者Yi, Shuying2,3; Niu, Rui2; Zhu, Guangming2; Liu, Jianguo2; Huang, Hua2; Wang, Yaping2; Jing, Xiuli2; Kang, Li2,3; Song, Wengang2,3; Tang, Hua2,4
刊名NATURE COMMUNICATIONS
出版日期2018
卷号9期号:-页码:3879
关键词3D anatomy reaction diffusion process systems modeling
ISSN号2041-1723
DOI10.1038/s41467-018-06316-9
文献子类Article
英文摘要Eosinophil infiltration, a hallmark of allergic asthma, is essential for type 2 immune responses. How the initial eosinophil recruitment is regulated by lung dendritic cell (DC) subsets during the memory stage after allergen challenge is unclear. Here, we show that the initial eosinophil infiltration is dependent on lung cDC1s, which require nitric oxide (NO) produced by inducible NO synthase from lung CD24(-)CD11b(+) DC2s for inducing CCL17 and CCL22 to attract eosinophils. During late phase responses after allergen challenge, lung CD24(+) cDC2s inhibit eosinophil recruitment through secretion of TGF-beta 1, which impairs the expression of CCL17 and CCL22. Our data suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically, through secreting distinct soluble factors during the memory stage of chronic asthma after allergen challenge in the mouse.
学科主题Science & Technology - Other Topics
WOS关键词AIRWAY INFLAMMATION ; NITRIC-OXIDE ; TH2 RESPONSES ; T-CELLS ; IN-VIVO ; ASTHMA ; MICE ; EXPRESSION ; IMMUNITY ; DISEASES
语种英语
WOS记录号WOS:000445329000014
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/754]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China,
2.Taishan Med Univ, Inst Immunol, Tai An 271000, Shandong, Peoples R China;
3.Taishan Med Univ, Sch Basic Med Sci, Tai An 271000, Shandong, Peoples R China;
4.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China;
推荐引用方式
GB/T 7714		 Yi, Shuying,Niu, Rui,Zhu, Guangming,et al. Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge[J]. NATURE COMMUNICATIONS,2018,9(-):3879.
APA Yi, Shuying.,Niu, Rui.,Zhu, Guangming.,Liu, Jianguo.,Huang, Hua.,...&,.(2018).Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.NATURE COMMUNICATIONS,9(-),3879.
MLA Yi, Shuying,et al."Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge".NATURE COMMUNICATIONS 9.-(2018):3879.

入库方式： OAI收割

来源：上海营养与健康研究所

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