Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population
文献类型：期刊论文
| 作者 | Pan, Hong1,2; Shen, Jun-Yi2; Du, Juan-Juan2; Cui, Shi-Shuang2; Liu, Jin2; Lin, Yi-Qi2; He, Yi-Xi2; Fu, Yang2; Gao, Chao2; Li, Gen2 |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2018 |
| 卷号 | 34期号:5页码:867-869 |
| ISSN号 | 1673-7067 |
| 关键词 | Fatty acid-binding protein 4 hepatocellular carcinoma poor prognosis proliferation and invasion |
| DOI | 10.1007/s12264-018-0233-7 |
| 文献子类 | Letter |
| 英文摘要 | Adipocyte fatty acid-binding protein (FABP4) is abundant in macrophage and adipocyte. It is known to be involved in lipid metabolism. The role of FABP4 has been reported in various cancers, such as non-smallcelllungcancer, breastcancer, ovariancancer, and prostatic cancer. However, its role remains unclear in hepatocellular carcinoma (HCC). In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinicalcharacteristics had been discussed. We found that FABP4 was lowly expressed in HCC tissues compared to the corresponding tissue adjacent, and the expression of FABP4 was significantly associated with the tumor size, PVTT, recurrence-free survival and overall survival. Moreover, multivariate Cox regression analysis indicated that the expression of FABP4, Alb, AFP, HBsAg, and PVTT were independent risk factors for overall survival, and the expression of FABP4, AFP, GGT, tumor size, and encapsulation were independent risk factors for HCC recurrence. In addition, we revealed that FABP4 suppressed HCC cell proliferation and invasion in vitro. Moreover, overexpression of FABP4 led to inhibit tumor growth and decreased tumor volume in vivo. These phenotypes were associated with altered expression of Snail and p-STAT3. Our studies thus suggest that FABP4 could be a potential target for HCC chemotherapy. |
| 学科主题 | Neurosciences & Neurology |
| WOS关键词 | ALPHA-SYNUCLEIN ; METHYLATION ; DNA |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000444005200018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/755]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Neurodegenerat Dis,Inst Hlth Sci, Shanghai 200031, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol & Collaborat Innovat,Ctr Brain Sci, Shanghai 200025, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Pan, Hong,Shen, Jun-Yi,Du, Juan-Juan,et al. Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population[J]. NEUROSCIENCE BULLETIN,2018,34(5):867-869. |
| APA | Pan, Hong.,Shen, Jun-Yi.,Du, Juan-Juan.,Cui, Shi-Shuang.,Liu, Jin.,...&,.(2018).Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population.NEUROSCIENCE BULLETIN,34(5),867-869. |
| MLA | Pan, Hong,et al."Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population".NEUROSCIENCE BULLETIN 34.5(2018):867-869. |
入库方式： OAI收割
来源：上海营养与健康研究所
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