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Effects of functional beta-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells

文献类型：期刊论文

作者Li, Yan2; Pan, Haiou2; Qian, Haifeng2; Qi, Xiguang2; Wu, Gangcheng2; Zhang, Hui2; Wang, Li2; Fan, Yihui3; Xu, Meijuan1; Rao, Zhiming1
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2018
卷号117期号:-页码:287-293
关键词beta-glucan Muscle C2C12
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2018.05.188
文献子类Article
英文摘要Skeletal muscles plays a crucial role in metabolism and exercise. Fuctional beta-glucan is polysaccharide that is found in the cell walls of cereal, which is known to reduce cholesterol and lipid, prevent diabetes, cancer and cardiovascular diseases. In an attempt to identify beta-glucan that could promote skeletal muscle function, we analyzed the proliferation, differentiation, metabolism and anti-fibrotic properties of beta-glucan in C2C12 muscle cells. Treatment of beta-glucan in C2C12 myoblasts led to increased proliferation and differentiation. Besides that, we found that C2C12 myotubes treated with beta-glucan displayed a fast-to-slow muscle fiber conversion and improved oxidative metabolism. Further study revealed that beta-glucan treatment could prevent myotubes from becoming myofibroblasts. Together, our study suggests that functional beta-glucan might have a therapeutic potential to improve skeletal muscle function, which might contribute to the development of beta-glucan. (C) 2018 Elsevier B.V. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS关键词SKELETAL-MUSCLE ; FIBER ; EXPRESSION ; GLUCOSE ; BIOLOGY ; PDK4
语种英语
WOS记录号WOS:000442057700033
出版者ELSEVIER SCIENCE BV
版本出版稿
源URL[http://202.127.25.144/handle/331004/756]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Jiangnan Univ, Sch Biotechnol, Lab Appl Microorganisms & Metab Engn, Key Lab Ind Biotechnol,Minist Educ, Wuxi 214122, Peoples R China;
2.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Lihu Ave 1800, Wuxi 214122, Peoples R China;
3.Nantong Univ, Sch Med, Dept Immunol, Nantong 226001, Peoples R China;
4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China,
推荐引用方式
GB/T 7714		 Li, Yan,Pan, Haiou,Qian, Haifeng,et al. Effects of functional beta-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,117(-):287-293.
APA Li, Yan.,Pan, Haiou.,Qian, Haifeng.,Qi, Xiguang.,Wu, Gangcheng.,...&,.(2018).Effects of functional beta-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,117(-),287-293.
MLA Li, Yan,et al."Effects of functional beta-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 117.-(2018):287-293.

入库方式： OAI收割

来源：上海营养与健康研究所

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