Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women
文献类型：期刊论文
| 作者 | Zong, Geng2,3; Hu, Frank B.3; Sampson, Laura3; Dougherty, Lauren W.3; Willett, Walter C.3,5,6,7; Sun, Qi3,5,6,7; Lebwohl, Benjamin4; Hu, Frank B.5,6,7; Chan, Andrew T.6,7; Chan, Andrew T.1,8,9 |
| 刊名 | DIABETOLOGIA
 |
| 出版日期 | 2018 |
| 卷号 | 61期号:10页码:2164-2173 |
| 关键词 | Gluten Type 2 diabetes |
| ISSN号 | 0012-186X |
| DOI | 10.1007/s00125-018-4697-9 |
| 文献子类 | Article |
| 英文摘要 | We investigated the association between gluten intake and long-term type 2 diabetes risk among Americans. We followed women from the Nurses' Health Study (NHS, n = 71,602, 1984-2012) and NHS II (n = 88,604, 1991-2013) and men from the Health Professionals Follow-Up Study (HPFS, n = 41,908, 1986-2012). Gluten intake was estimated using a validated food frequency questionnaire every 2-4 years. Incident type 2 diabetes was defined as self-reported physician-diagnosed diabetes confirmed using a supplementary questionnaire. Gluten intake was strongly correlated with intakes of carbohydrate components, especially refined grains, starch and cereal fibre (Spearman correlation coefficients > 0.6). During 4.24 million years of follow-up, 15,947 people were confirmed to have type 2 diabetes. After multivariate adjustment, pooled HRs and 95% CIs for type 2 diabetes, from low to high gluten quintiles, were (p (trend) < 0.001): 1 (reference); 0.89 (0.85, 0.93); 0.84 (0.80, 0.88); 0.78 (0.74, 0.82) and 0.80 (0.76, 0.84). The association was slightly weakened after further adjusting for cereal fibre, with pooled HRs (95% CIs) of (p (trend) < 0.001): 1 (reference); 0.91 (0.87, 0.96); 0.88 (0.83, 0.93); 0.83 (0.78, 0.88) and 0.87 (0.81, 0.93). Dose-response analysis supported a largely linear inverse relationship between gluten intake up to 12 g/day and type 2 diabetes. The association between gluten intake and type 2 diabetes was stronger when intake of added bran was also higher (p (interaction) = 0.02). Gluten intake is inversely associated with type 2 diabetes risk among largely healthy US men and women. Limiting gluten in the diet is associated with lower intake of cereal fibre and possibly other beneficial nutrients that contribute to good health. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | BODY-MASS INDEX ; CELIAC-DISEASE ; FREE-DIET ; SERUM-LIPIDS ; PHYSICAL-ACTIVITY ; WHEAT ; PROTEIN ; CARBOHYDRATE ; QUESTIONNAIRE ; CONSUMPTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000443448100011 |
| 出版者 | SPRINGER |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/758]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Nutr Metab & Food Safety,Inst Nutr &, Shanghai, Peoples R China; 3.Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA; 4.Columbia Univ Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA; 5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; 6.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 7.Harvard Med Sch, Boston, MA 02115 USA; 8.Massachusetts Gen Hosp, Div Gastroenterol, 55 Fruit St, Boston, MA 02114 USA; 9.Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA, |
| 推荐引用方式 GB/T 7714 | Zong, Geng,Hu, Frank B.,Sampson, Laura,et al. Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women[J]. DIABETOLOGIA,2018,61(10):2164-2173. |
| APA | Zong, Geng.,Hu, Frank B..,Sampson, Laura.,Dougherty, Lauren W..,Willett, Walter C..,...&,.(2018).Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women.DIABETOLOGIA,61(10),2164-2173. |
| MLA | Zong, Geng,et al."Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women".DIABETOLOGIA 61.10(2018):2164-2173. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。