Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer
文献类型：期刊论文
| 作者 | Xiao, Qingyu2; Sun, Yidi2; Zhao, Guo-Ping2; Li, Yixue2; Li, Hong2; Dobi, Albert3,4; Srivastava, Shiv3,4; Wang, Wendy1; Srivastava, Sudhir1; Ji, Yuan5 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:-页码:12868 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-018-30325-9 |
| 文献子类 | Article |
| 英文摘要 | The TMPRSS2:ERG gene fusion is the most prevalent early driver gene activation in prostate cancers of European ancestry, while the fusion frequency is much lower in Africans and Asians. The genomic characteristics and mechanisms for patients lacking ERG fusion are still unclear. In this study, we systematically compared the characteristics of gene fusions, somatic mutations, copy number alterations and gene expression signatures between 201 ERG fusion positive and 296 ERG fusion negative prostate cancer samples. Both common and group-specific genomic alterations were observed, suggesting shared and different mechanisms of carcinogenesis in prostate cancer samples with or without ERG fusion. The genomic alteration patterns detected in ERG-negative group showed similarities with 77.5% of tumor samples of African American patients. These results emphasize that genomic and gene expression features of the ERG-negative group may provide a reference for populations with lower ERG fusion frequency. While the overall expression patterns were comparable between ERG-negative and ERG-positive tumors, we found that genomic alterations could affect the same pathway through distinct genes in the same pathway in both groups of tumor types. Altogether, the genomic and molecular characteristics revealed in our study may provide new opportunities for molecular stratification of ERG-negative prostate cancers. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | TMPRSS2-ERG GENE FUSION ; MUTATIONAL LANDSCAPE ; ANDROGEN RECEPTOR ; GENOMIC DATA ; EXPRESSION ; COHORT ; PROGRESSION ; CELLS ; HETEROGENEITY ; REARRANGEMENT |
| 语种 | 英语 |
| WOS记录号 | WOS:000442870300046 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/764]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.NCI, Canc Biomarkers Res Grp, Div Canc Prevent, Bethesda, MD 20892 USA; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth,CAS Key Lab Computat Bi, CAS MPG Partner Inst Computat Biol,Shanghai Inst, Shanghai, Peoples R China; 3.Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA; 4.Walter Reed Natl Mil Med Ctr, Bethesda, MD USA; 5.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xiao, Qingyu,Sun, Yidi,Zhao, Guo-Ping,et al. Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer[J]. SCIENTIFIC REPORTS,2018,8(-):12868. |
| APA | Xiao, Qingyu.,Sun, Yidi.,Zhao, Guo-Ping.,Li, Yixue.,Li, Hong.,...&,.(2018).Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.SCIENTIFIC REPORTS,8(-),12868. |
| MLA | Xiao, Qingyu,et al."Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer".SCIENTIFIC REPORTS 8.-(2018):12868. |
入库方式： OAI收割
来源：上海营养与健康研究所
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