Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
文献类型：期刊论文
| 作者 | Chang, Renxu1; Song, Lele1; Xu, Yi1; Wu, Yanjun1; Dai, Cheng1; Wang, Xinyu1; Sun, Xia1; Zhan, Lixing1; Hou, Yingyong2; Li, Wei3 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:-页码:3486 |
| 关键词 | breast cancer metastasis partner and localizer of BRCA2 prognosis |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-05852-8 |
| 文献子类 | Article |
| 英文摘要 | Loss of WW domain-containing oxidoreductase (Wwox) expression has been observed in breast cancer (BC). However, its regulatory effects are largely unknown, especially in triple-negative breast cancer (TNBC). Herein, gene expression profiling revealed that JAK/STAT3 pathway was one of the most differentially modulated pathways in basal-like BC cells. The lower expression of Wwox was significantly correlated with high activation of STAT3 in basal-like cells and TNBC tissues. Overexpression of Wwox markedly inhibited proliferation and metastasis of BC cells by suppressing STAT3 activation, which is to interact with JAK2 to inhibit JAK2 and STAT3 phosphorylation. Furthermore, Wwox limited STAT3 binding to the interleukin-6 promoter, repressing expression of the IL-6 cytokine. Altogether, our data established that Wwox suppresses BC cell metastasis and proliferation by JAK2/STAT3 pathway. Targeting of Wwox with STAT3 could offer a promising therapeutic strategy for TNBC. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | DOMAIN-CONTAINING OXIDOREDUCTASE ; TUMOR-SUPPRESSOR PROTEIN ; GENE-EXPRESSION ; INTERLEUKIN-6 SYNTHESIS ; PRECLINICAL MODELS ; CLINICAL-FEATURES ; MULTIPLE-MYELOMA ; LEVELS CORRELATE ; IMMUNE-SYSTEM ; KAPPA-B |
| 语种 | 英语 |
| WOS记录号 | WOS:000442909300010 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/766]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Key Lab Nutr Metab & Food Safety, Inst Nutr & Hlth, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 2.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200032, Peoples R China; 3.Zhejiang Univ, Dept Gen Surg, Coll Med, Sir Run Run Shaw Hosp, Hangzhou 310020, Zhejiang, Peoples R China; 4.Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai 200433, Peoples R China; 5.Fudan Univ, Sch Basic Med Sci, Dept Cellular & Genet Med, Key Lab Metab & Mol Med,Minist Educ, Shanghai 200032, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chang, Renxu,Song, Lele,Xu, Yi,et al. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis[J]. NATURE COMMUNICATIONS,2018,9(-):3486. |
| APA | Chang, Renxu.,Song, Lele.,Xu, Yi.,Wu, Yanjun.,Dai, Cheng.,...&,.(2018).Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis.NATURE COMMUNICATIONS,9(-),3486. |
| MLA | Chang, Renxu,et al."Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis".NATURE COMMUNICATIONS 9.-(2018):3486. |
入库方式： OAI收割
来源：上海营养与健康研究所
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