Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells
文献类型：期刊论文
| 作者 | Wang, Xiong-jun3,7; Xiao, Minzhe M.3; Wang, Yumei3; Tan, Ming-dian3; Huang, Chao3; Chin, Y. Eugene3; Hou, Zhaoyuan7; Qiao, Yunbo1,2; Wang, Lingbo1; Chen, Jun1 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 18期号:4页码:933-946 |
| 关键词 | Epigenetic regulation Epigenetic factor Random walk with restart Protein-protein interaction network |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2016.12.081 |
| 文献子类 | Article |
| 英文摘要 | LIF promotes self-renewal of mouse embryonic stem cells (mESCs), and in its absence, the cells differentiate. LIF binds to the LIF receptor (LIFR) and activates the JAK-STAT3 pathway, but it remains unknown how the receptor complex triggers differentiation or self-renewal. Here, we report that the LIFR cytoplasmic domain contains a self-renewal domain within the juxtamembrane region and a differentiation domain within the C-terminal region. The differentiation domain contains four SPXX repeats that are phosphorylated by MAPK to restrict STAT3 activation; the self-renewal domain is characterized by a 3K motif that is acetylated by p300. In mESCs, acetyl-LIFR undergoes homodimerization, leading to STAT3 hypo- or hyper-activation depending on the presence or absence of gp130. LIFR-activated STAT3 restricts differentiation via cytokine induction. Thus, LIFR acetylation and serine phosphorylation differentially promote stem cell self-renewal and differentiation. |
| 学科主题 | Cell Biology |
| WOS关键词 | LEUKEMIA INHIBITORY FACTOR ; PHASE RESPONSE FACTOR/STAT3 ; PROTEIN-KINASE ; GROUND-STATE ; DIFFERENTIAL ACTIVATION ; CYTOPLASMIC DOMAINS ; CYTOKINE RECEPTORS ; TRANSDUCER GP130 ; SINGLE CELLS ; PLURIPOTENCY |
| 语种 | 英语 |
| WOS记录号 | WOS:000396474300010 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/767]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 2.Shanghai Tech Univ, IHuman Inst, 99 Haike Rd, Shanghai 201210, Peoples R China; 3.Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci,Sch Med, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.Nankai Univ, Dept Genet & Cell Biol, Coll Life Sci, Tianjin 300071, Peoples R China; 5.Zhejiang Chinese Med Univ, Sch Basic Med, Dept Signal Transduct, Hangzhou 310053, Zhejiang, Peoples R China; 6.Boston Univ, Dept Surg, Roger Williams Med Ctr, Sch Med, Providence, RI 02908 USA, 7.Shanghai Jiao Tong Univ, Hongqiao Inst Med, Sch Med, Shanghai Tongren Hosp,Fac Basic Med, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Xiong-jun,Xiao, Minzhe M.,Wang, Yumei,et al. Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells[J]. CELL REPORTS,2017,18(4):933-946. |
| APA | Wang, Xiong-jun.,Xiao, Minzhe M..,Wang, Yumei.,Tan, Ming-dian.,Huang, Chao.,...&,.(2017).Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells.CELL REPORTS,18(4),933-946. |
| MLA | Wang, Xiong-jun,et al."Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells".CELL REPORTS 18.4(2017):933-946. |
入库方式： OAI收割
来源：上海营养与健康研究所
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