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Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians

文献类型：期刊论文

作者Li, Changwei2,3; He, Jiang3; Zhao, Jinying3; Kelly, Tanika N.3; Kim, Yun Kyoung4; Lee, Juyoung4; Han, Sohee4; Han, Bok-Ghee4; Moon, Sanghoon4; Kim, Bong-Jo4
刊名CIRCULATION-CARDIOVASCULAR GENETICS
出版日期2017
卷号10期号:2页码:UNSP e001527
关键词arterial pressure blood pressure epidemiology genome-wide association study
ISSN号1942-325X
DOI10.1161/CIRCGENETICS.116.001527
文献子类Article
英文摘要Background-Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP. Methods and Results-We conducted genome-wide analysis among 18422 East Asian participants (stage 1) followed by replication study of <= 46629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a P<5.0x10(-8) and 2.5x10(-6), respectively, in joint analyses of stage-1 and stage-2 data. We identified 1 novel ARL3 variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1 P=5.03x10(-8), stage-2 P=8.64x10(-3), joint P=2.63x10(-8)) and mean arterial pressure (stage-1 P=3.59x10(-9), stage-2 P=2.35x10(-2), joint P=2.64x10(-8)). Three previously reported BP loci (WBP1L, NT5C2, and ATP2B1) were also identified for all BP phenotypes. Gene-based analysis provided the first robust evidence for association of KCNJ11 with LTA systolic BP (stage-1 P=8.55x10(-6), stage-2 P=1.62x10(-5), joint P=3.28x10(-9)) and mean arterial pressure (stage-1 P=9.19x10(-7), stage-2 P=9.69x10(-5), joint P=2.15x10(-9)) phenotypes. Fourteen genes (TMEM180, ACTR1A, SUFU, ARL3, SFXN2, WBP1L, CYP17A1, C10orf32, C10orf32-ASMT, AS3MT, CNNM2, and NT5C2 at 10q24.32; ATP2B1 at 12q21.33; and NCR3LG1 at 11p15.1) implicated by previous genome-wide association study meta-analyses were also identified. Among the loci identified by the previous genome-wide association study meta-analysis of LTA BP, we transethnically replicated associations of the KCNK3 marker rs1275988 at 2p23.3 with LTA systolic BP and mean arterial pressure phenotypes (P=1.27x10(-4) and 3.30x10(-4), respectively). Conclusions-We identified 1 novel variant and 1 novel gene and present the first direct evidence of relevance of the KCNK3 locus for LTA BP among East Asians.
学科主题Cardiovascular System & Cardiology ; Genetics & Heredity
WOS关键词CARDIOVASCULAR-DISEASE RISK ; BARDET-BIEDL SYNDROME ; SINGAPORE MALAY EYE ; GENETIC-VARIANTS ; GENOTYPE IMPUTATION ; GLOBAL BURDEN ; DESIGN ; POPULATION ; SUSCEPTIBILITY ; HYPERTENSION
语种英语
WOS记录号WOS:000397822400004
出版者LIPPINCOTT WILLIAMS & WILKINS
版本出版稿
源URL[http://202.127.25.144/handle/331004/771]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Beijing 100864, Peoples R China;
2.Univ Georgia, Dept Epidemiol & Biostat, Athens, GA 30602 USA;
3.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St,Suite 2000, New Orleans, LA 70112 USA;
4.Osong Hlth Technol Adm Complex, Korea Natl Inst Hlth, Ctr Genome Sci, Cheongju, Chungcheongbuk, South Korea;
5.Genome Inst Singapore, Agcy Sci Technol & Res, Singapore, Singapore;
6.Chinese Acad Sci, Grad Univ, Beijing 100864, Peoples R China;
7.Natl Yang Ming Univ Hosp, Taipei, Taiwan;
8.Singapore Eye Res Inst, Singapore Natl Eye Ctr, Singapore, Singapore;
9.Natl Univ Singapore, Duke NUS Grad Med Sch, Singapore 117548, Singapore;
10.Natl Univ Hlth Syst, Dept Ophthalmol, Singapore, Singapore;
推荐引用方式
GB/T 7714		 Li, Changwei,He, Jiang,Zhao, Jinying,et al. Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians[J]. CIRCULATION-CARDIOVASCULAR GENETICS,2017,10(2):UNSP e001527.
APA Li, Changwei.,He, Jiang.,Zhao, Jinying.,Kelly, Tanika N..,Kim, Yun Kyoung.,...&,.(2017).Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.CIRCULATION-CARDIOVASCULAR GENETICS,10(2),UNSP e001527.
MLA Li, Changwei,et al."Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians".CIRCULATION-CARDIOVASCULAR GENETICS 10.2(2017):UNSP e001527.

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来源：上海营养与健康研究所

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