Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-C alpha by ubiquitin-proteasome system
文献类型：期刊论文
| 作者 | Fan, Fangzhi2; Weng, Lietao2; Chen, Guoqiang2,3; Xu, Ying2; Zhao, Junxing3; Li, Qingqing3; Liu, Yali1,4; Zhao, Hongfang1,4; , |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 500期号:3页码:676-681 |
| 关键词 | FAM122A SUMO1 modification PP2A Ubiquitination Phosphatase activity |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2018.04.135 |
| 文献子类 | Article |
| 英文摘要 | FAM122A is a highly conserved protein in mammals. Here, we identify that FAM122A can be sumoylated at lysine 89, which can be de-conjugated by SENPI. Furthermore, the sumoylation of FAM122A reduces the PP2A-Ca protein level together with the reduced phosphatase activity of PP2A, which suppresses cell proliferation. Collectively, our results suggest that the sumoylation of FAM122A may have a significant role in cellular function. (C) 2018 The Authors. Published by Elsevier Inc. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| WOS关键词 | PROTEIN PHOSPHATASE 2A ; TUMOR-SUPPRESSOR PP2A ; C-ALPHA ; CELLS ; DIFFERENTIATION ; METASTASIS ; CANCER ; E3 |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31776999 |
| WOS记录号 | WOS:000433267800025 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/776]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China; 2.Shanghai Jiao Tong Univ, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis, Rui Jin Hosp,Sch Med,Chinese Minist Educ, Shanghai 200025, Peoples R China; 3.Shanghai Jiao Tong Univ, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis, Sch Med,Chinese Minist Educ, Shanghai 200025, Peoples R China; 4.SJTU SM, Shanghai 200025, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Fan, Fangzhi,Weng, Lietao,Chen, Guoqiang,et al. Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-C alpha by ubiquitin-proteasome system[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,500(3):676-681. |
| APA | Fan, Fangzhi.,Weng, Lietao.,Chen, Guoqiang.,Xu, Ying.,Zhao, Junxing.,...&,.(2018).Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-C alpha by ubiquitin-proteasome system.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,500(3),676-681. |
| MLA | Fan, Fangzhi,et al."Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-C alpha by ubiquitin-proteasome system".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 500.3(2018):676-681. |
入库方式： OAI收割
来源：上海营养与健康研究所
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