Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences
文献类型：期刊论文
| 作者 | Wei, Lan-Hai8,9,10; Wang, Ling-Xiang8,9; Wen, Shao-Qing8,9; Yan, Shi8,9; Huang, Yun-Zhi8,9; Jin, Li8,9; Li, Hui8,9; Xu, Shuhua4,5,9; Canada, Rebekah11; Biondo, Alessandro11 |
| 刊名 | EUROPEAN JOURNAL OF HUMAN GENETICS
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| 出版日期 | 2018 |
| 卷号 | 26期号:11页码:1687-1696 |
| 关键词 | autophagy Hashimoto's thyroiditis interleukin-23 reactive oxygen species AKT/mTOR/NF-kappa B |
| ISSN号 | 1018-4813 |
| DOI | 10.1038/s41431-018-0211-6 |
| 文献子类 | Article |
| 英文摘要 | The expansion of modern humans to the American continent after the Last Glacial Maximum led the way to the present-day distribution of American aborigines. Recent advances in autosomal DNA research and expanded testing of mtDNA lineages has provided a clearer picture of the number and timing of founding lineages. However, both autosomal DNA and mtDNA research have provided unresolved competing theories between the short-term and the long-term models of the Beringian standstill hypothesis. Further, the source of founding paternal lineages of American aborigines and their relationship with ancient Siberia populations remains ambiguous. In this study, we reanalyzed a 7.0 Mbp region of 132 paternal Y-chromosome sequences, including 39 newly reported ones, of male samples from American aborigines and Eurasian populations. Among Eurasian samples, we identified Y-chromosome branches that are most closely related to known American aborigine founding lineages, that is, Q1-L804 links to Q1-M3, Q1-L330 links to Q1-Z780, Q1-M120 links to Q1-B143, and C2-F1756 links to C2-P39. The revised phylogenetic tree and age estimates indicate a narrow timeframe (similar to 15.3-14.3 kya) for the upper time limit of human entry to the American continent. Our analysis suggests that the in situ differentiation of Q-M242 in Central Eurasia and South Siberia region gave rise to numerous sub-lineages older than 15.3 kya, and the founding of Paleo-Indian paternal lineages is part of the great Q1 -L53 diffusion throughout the Eurasia after the Last Glacial Maximum. The results of our study will assist in future studies of the history of modern populations in Eurasia and the Americas. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | NATIVE-AMERICANS ; MITOCHONDRIAL-DNA ; GENOME SEQUENCE ; MODERN HUMANS ; ANCIENT DNA ; NEW-WORLD ; POPULATIONS ; ANCESTRY ; CLOVIS ; DISPERSAL |
| 语种 | 英语 |
| WOS记录号 | WOS:000447273900017 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/778]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Vavilov Inst Gen Genet, Moscow 119991, Russia; 2.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA; 3.Xiamen Univ, Dept Anthropol & Ethnol, Xiamen 361005, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol PICB, Key Lab Computat Biol,Max Planck Independent Res, Shanghai 200031, Peoples R China; 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China, 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 8.Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 20043, Peoples R China; 9.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China; 10.Inst Natl Langues & Civilisat Orientales, F-75214 Paris, France; |
| 推荐引用方式 GB/T 7714 | Wei, Lan-Hai,Wang, Ling-Xiang,Wen, Shao-Qing,et al. Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences[J]. EUROPEAN JOURNAL OF HUMAN GENETICS,2018,26(11):1687-1696. |
| APA | Wei, Lan-Hai.,Wang, Ling-Xiang.,Wen, Shao-Qing.,Yan, Shi.,Huang, Yun-Zhi.,...&,.(2018).Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences.EUROPEAN JOURNAL OF HUMAN GENETICS,26(11),1687-1696. |
| MLA | Wei, Lan-Hai,et al."Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences".EUROPEAN JOURNAL OF HUMAN GENETICS 26.11(2018):1687-1696. |
入库方式： OAI收割
来源：上海营养与健康研究所
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