Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis
文献类型：期刊论文
| 作者 | Shan, Lingjuan2,3; Wu, Chan2,3; Li, Xin2; Wang, Lixia2; Wang, Zhaohui2; Chen, Di3; Chu, Xiao3; Hou, Lei4; Hou, Yifeng1,5; Chu, Xiao6 |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2017 |
| 卷号 | 44期号:2页码:95-106 |
| ISSN号 | 1673-8527 |
| 关键词 | Germ cell Mitosis to meiosis Alternative polyadenylation RNA-binding protein 3 ' UTR |
| DOI | 10.1016/j.jgg.2016.12.007 |
| 文献子类 | Article |
| 英文摘要 | In the sexually reproductive organisms, gametes are produced by meiosis following a limited mitotic amplification. However, the intrinsic program switching cells from mitotic to meiotic cycle is unclear. Alternative polyadenylation (APA) is a highly conserved means of gene regulation and is achieved by the RNA 3'-processing machinery to generate diverse 3'UTR profiles. In Drosophila spermatogenesis, we observed distinct profiles of transcriptome-wide 3'UTR between mitotic and meiotic cells. In mutant germ cells stuck in mitosis, 3'UTRs of hundreds of genes were consistently shifted. Remarkably, altering the levels of multiple 3'-processing factors disrupted germline's progression to meiosis, indicative of APA's active role in this transition. An RNA-binding protein (RBP) Tut could directly bind 3'UTRs of 3'-processing factors whose expressions were repressed in the presence of Tut-containing complex. Further, we demonstrated that this RBP complex could execute the repression post-transcriptionally by recruiting CCR4/Twin of deadenylation complex. Thus, we propose that an RBP complex regulates the dynamic APA profile to promote the mitosis-to-meiosis transition. Copyright (C) 2017, The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | 3' UNTRANSLATED REGIONS ; STEM-CELL LINEAGE ; CLEAVAGE FACTOR IM ; PRE-MESSENGER-RNA ; BAG-OF-MARBLES ; MEIOTIC INITIATION ; RETINOIC ACID ; DIFFERENTIATION ; DROSOPHILA ; PROTEIN |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000395458600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/780]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China; 2.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 5.Chinese Acad Sci, Inst Genet & Dev Biol, Natl Ctr Plant Gene Res, Beijing 100101, Peoples R China; 6.Chinese Acad Sci, Inst Genet & Dev Biol, Collaborat Innovat Ctr Genet & Dev, Key Lab Genet Network Biol, Beijing 100101, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Shan, Lingjuan,Wu, Chan,Li, Xin,et al. Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis[J]. JOURNAL OF GENETICS AND GENOMICS,2017,44(2):95-106. |
| APA | Shan, Lingjuan.,Wu, Chan.,Li, Xin.,Wang, Lixia.,Wang, Zhaohui.,...&,.(2017).Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis.JOURNAL OF GENETICS AND GENOMICS,44(2),95-106. |
| MLA | Shan, Lingjuan,et al."Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis".JOURNAL OF GENETICS AND GENOMICS 44.2(2017):95-106. |
入库方式： OAI收割
来源：上海营养与健康研究所
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