An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
文献类型：期刊论文
| 作者 | Crewe, Clair2; Joffin, Nolwenn2; Rutkowski, Joseph M.2; Kim, Min2; Zhang, Fang2; Gordillo, Ruth2; Scherer, Philipp E.2; Kim, Min3; Zhang, Fang4; Towler, Dwight A.1 |
| 刊名 | CELL
 |
| 出版日期 | 2018 |
| 卷号 | 175期号:3页码:695-+ |
| 关键词 | Hepatocellular carcinoma Methylation CpG island methylator phenotype Gene regulation Specific diagnostic biomarker |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2018.09.005 |
| 文献子类 | Article |
| 英文摘要 | We have uncovered the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue (AT) proper. This phenomenon became evident in our attempts at generating an adipocyte-specific knockout of caveolin 1 (cav1) protein. Although we effectively ablated the CAV1 gene in adipocytes, cav1 protein remained abundant. With the use of newly generated mouse models, we show that neighboring endothelial cells (ECs) transfer cav1-containing EVs to adipocytes in vivo, which reciprocate by releasing EVs to ECs. AT-derived EVs contain proteins and lipids capable of modulating cellular signaling pathways. Furthermore, this mechanism facilitates transfer of plasma constituents from ECs to the adipocyte. The transfer event is physiologically regulated by fasting/refeeding and obesity, suggesting EVs participate in the tissue response to changes in the systemic nutrient state. This work offers new insights into the complex signaling mechanisms that exist among adipocytes, stromal vascular cells, and, potentially, distal organs. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | ADIPOSE-TISSUE ; GENE-EXPRESSION ; EXOSOMES ; CELLS ; CAVEOLIN-1 ; OBESITY ; IDENTIFICATION ; INFLAMMATION ; CANCER ; PHOSPHORYLATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000447780800013 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/782]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Texas Southwestern Med Ctr Dallas, Endocrine Div, Dept Internal Med, Dallas, TX 75390 USA, 2.Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA; 3.Inje Univ, CMDC, Busan, South Korea; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Crewe, Clair,Joffin, Nolwenn,Rutkowski, Joseph M.,et al. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State[J]. CELL,2018,175(3):695-+. |
| APA | Crewe, Clair.,Joffin, Nolwenn.,Rutkowski, Joseph M..,Kim, Min.,Zhang, Fang.,...&,.(2018).An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.CELL,175(3),695-+. |
| MLA | Crewe, Clair,et al."An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State".CELL 175.3(2018):695-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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