Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening
文献类型：期刊论文
| 作者 | Ji, Shuyi2; Zhu, Linying2; Gao, Yimeng2; Yan, Yupeng2; Cen, Jin2; Hui, Lijian2; Zhang, Xiaoran3; Wei, Gang3; Li, Rongxia4; Zeng, Rong4 |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:5页码:642-656 |
| 关键词 | Baf60b ATM p53 chromatin remodeling lineage conversion hepatic conversion |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2017.36 |
| 文献子类 | Article |
| 英文摘要 | Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1 alpha and Gata4 (3TF) to induce hepatic conversion in mouse fibroblasts, we showed that 3TF induced strong activation of the ATM-p53 pathway, which led to proliferation arrest and cell death, and it further prevented hepatic conversion. Notably, ATM activation, independent of DNA damage, responded to chromatin opening during hepatic conversion. By characterizing the early molecular events during hepatic conversion, we found that Baf60b, a member of the SWI/SNF chromatin remodeling complex, links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci. These findings shed light on cellular responses to lineage conversion by revealing a function of the ATM-p53 pathway in sensing chromatin opening. |
| 学科主题 | Cell Biology |
| WOS关键词 | DNA-DAMAGE ; DEFINED FACTORS ; CANCER-THERAPY ; SOMATIC-CELLS ; P53 PATHWAY ; IPS CELLS ; FIBROBLASTS ; MECHANISMS ; ATM ; PLURIPOTENCY |
| 语种 | 英语 |
| WOS记录号 | WOS:000400443300008 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/783]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China; 5.East China Normal Univ, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China; 6.South Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China; 7.Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Clin & Translat Res Ctr,Shanghai Maternity & Infa, Shanghai 200092, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ji, Shuyi,Zhu, Linying,Gao, Yimeng,et al. Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening[J]. CELL RESEARCH,2017,27(5):642-656. |
| APA | Ji, Shuyi.,Zhu, Linying.,Gao, Yimeng.,Yan, Yupeng.,Cen, Jin.,...&,.(2017).Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.CELL RESEARCH,27(5),642-656. |
| MLA | Ji, Shuyi,et al."Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening".CELL RESEARCH 27.5(2017):642-656. |
入库方式： OAI收割
来源：上海营养与健康研究所
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