Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells
文献类型：期刊论文
| 作者 | Sun, Yixuan2,3; Yuan, Xinlu2; Chang, Xinxia2; Xu, Xi2; Gao, Xin2,3; Zhang, Feifei1; Han, Yamei1; Li, Yu1; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:11340 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-11860-3 |
| 文献子类 | Article |
| 英文摘要 | Oxidative stress is thought to be critical for the pathogenesis of hepatic steatosis and its progress to non-alcoholic steatohepatitis. Berberine (BBR) can improve hepatic steatosis. In this study, we investigated the role of BBR in ameliorating oxidative stress. Lipid accumulation was measured in the livers of C57BL/6 mice fed a high fat diet (HFD) or a normal diet for 8 weeks, then either received BBR or vehicle for the study duration. Nrf2 distribution was detected in male Sprague-Dawley rats' livers in vivo and in Huh7 cells in vitro. ROS generation and mitochondrial complex expression was measured in Huh7 cells. HepG2 cells were employed for the measurement of oxygen consumption rates. Our results showed that BBR reduced triglyceride accumulation in the liver of HFD-fed mice. The activation and nuclear distribution of Nrf2 was decreased in the hepatocytes of rats that received BBR treatment, while on a HFD. BBR also markedly reduced Nox2-dependent cytoplasmic ROS production and mitochondrial ROS production, which was mediated by the down-regulation of Complex I and III expression. In conclusion, BBR has a great potential to reduce the effects of oxidative stress, which likely contributes to its protective effect in inhibiting the progression of hepatic steatosis to steatohepatitis. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | NONALCOHOLIC STEATOHEPATITIS ; LIVER-DISEASE ; MITOCHONDRIAL ; NRF2 ; MECHANISM ; ANTIOXIDANTS ; EXPRESSION ; PATHOLOGY |
| 语种 | 英语 |
| WOS记录号 | WOS:000410297900054 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/784]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, CAS Key Lab Nutr & Metab, Shanghai 200031, Peoples R China, 2.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China; 3.Fudan Inst Metab Dis, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Sun, Yixuan,Yuan, Xinlu,Chang, Xinxia,et al. Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells[J]. SCIENTIFIC REPORTS,2017,7(-):11340. |
| APA | Sun, Yixuan.,Yuan, Xinlu.,Chang, Xinxia.,Xu, Xi.,Gao, Xin.,...&,.(2017).Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells.SCIENTIFIC REPORTS,7(-),11340. |
| MLA | Sun, Yixuan,et al."Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells".SCIENTIFIC REPORTS 7.-(2017):11340. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。