CNVbase: Batch identification of novel and rare copy number variations based on multi-ethnic population data
文献类型：期刊论文
| 作者 | Zhang, Cheng3,4,5; Lu, Jianqi3,4; Du, Renqian3; Zhang, Feng3,4; Jin, Li3; Shen, Yiping5; Lou, Haiyi6; Xu, Shuhua6; Xu, Shuhua1; Shen, Yiping2,7 |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2017 |
| 卷号 | 44期号:7页码:367-370 |
| 关键词 | beta-glucan Muscle C2C12 |
| ISSN号 | 1673-8527 |
| DOI | 10.1016/j.jgg.2017.07.001 |
| 文献子类 | Letter |
| 英文摘要 | Macrophage migration inhibitory factor (MIF) is a non-canonical cytokine that is involved in multiple inflammatory diseases, including atherosclerosis. High MIF expression found in leukocytes which facilitates the initiation and progression of atherosclerosis. However, little is known about biomechanical forces in the induction of MIF in endothelial cells (ECs). Here, we show that laminar shear stress (LS) inhibits the expression of MIF in ECs. By profiling the whole transcriptome of human coronary artery ECs under different shear stress, we found that athero-protective LS attenuates the expression of MIF whereas pro-atherosclerotic oscillatory shear stress (OS) significantly increased the expression of MIF. En face staining of rabbit aorta revealed high MIF immunoreactivity in lesser curvature as well as arterial bifurcation areas where OS is predominant. Mechanistically, we found that Krupple like factor 2 (KLF2) is required for inhibition of MIF expression in ECs in the context of shear stress. Knockdown of KLF2 abolishes LS-dependent MIF inhibition while overexpression of KLF2 significantly attenuated MIF expression. Overall, the present work showed that MIF is a shear stress-sensitive cytokine and is transcriptionally regulated by KLF2, suggesting that LS exerts its athero-protective effect in part by directly inhibiting pro-inflammatory MIF expression. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | HUMAN GENOME ; STRUCTURAL VARIATION ; SCALE ; VARIANTS |
| 语种 | 英语 |
| WOS记录号 | WOS:000406933500005 |
| 出版者 | SCIENCE PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/785]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 2.Shanghai Childrens Med Ctr, Dept Med Genet, Shanghai 200127, Peoples R China, 3.Fudan Univ, Obstet & Gynecol Hosp, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200438, Peoples R China; 4.Fudan Univ, Inst Reprod & Dev, Key Lab Reprod Regulat NPFPC, Shanghai 200011, Peoples R China; 5.Harvard Med Sch, Boston Childrens Hosp, Dept Lab Med & Pathol, Boston, MA 02115 USA; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Max Planck Independent Res Grp Populat Genom,CAS, Shanghai 200031, Peoples R China; 7.Childrens Hosp, Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Dept Genet Metab, Nanning 530003, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Cheng,Lu, Jianqi,Du, Renqian,et al. CNVbase: Batch identification of novel and rare copy number variations based on multi-ethnic population data[J]. JOURNAL OF GENETICS AND GENOMICS,2017,44(7):367-370. |
| APA | Zhang, Cheng.,Lu, Jianqi.,Du, Renqian.,Zhang, Feng.,Jin, Li.,...&,.(2017).CNVbase: Batch identification of novel and rare copy number variations based on multi-ethnic population data.JOURNAL OF GENETICS AND GENOMICS,44(7),367-370. |
| MLA | Zhang, Cheng,et al."CNVbase: Batch identification of novel and rare copy number variations based on multi-ethnic population data".JOURNAL OF GENETICS AND GENOMICS 44.7(2017):367-370. |
入库方式： OAI收割
来源：上海营养与健康研究所
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