Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population
文献类型：期刊论文
| 作者 | Liu, Yu5; Gao, Wenshan5; Li, Bingjie5; Peng, Qianqian5; Wu, Sijie5; Ding, Anan5; Jin, Li2,3,5; Wang, Sijia2,3,5; Koellmann, Claudia6; Huls, Anke6 |
| 刊名 | JOURNAL OF DERMATOLOGICAL SCIENCE
 |
| 出版日期 | 2019 |
| 卷号 | 96期号:1页码:42-49 |
| 关键词 | Skin aging Chinese Han females GWAS Candidate SNPs |
| ISSN号 | 0923-1811 |
| DOI | 10.1016/j.jdermsci.2019.08.010 |
| 文献子类 | Article |
| 英文摘要 | Background: The progression of human skin aging has a strong genetic basis. However, recent studies have mainly focused on Caucasian populations and we have thus performed a genetic association study on skin aging signs in Han Chinese population. Objective: To investigate genetic risk factors in skin aging in Han Chinese female, we performed a genome-wide association study. Methods: We collected genotype data from 1534 Han Chinese female from Taizhou cohort and evaluated 15 skin aging phenotypes by using the validated skin aging SCINEXA (TM) score. Genetic associations were tested by linear and logistic regression analyses and adjusted for potential confounders. Results: Six genomic regions significantly associated with a risk for skin aging were revealed : 6q24.2 (rs3804540, P = 4.6 x 10(-9), additive model) with size of pigmented spots on forehead, 10q26.13 (rs4962295, P = 1.9 x 10(-8), additive model) with wrinkles under eyes, 15q21.1 (rs28392847, P = 1.6 x 10(-8), additive model) with crow's feet, 2p25.1 (rs191497052, P = 5.5 x 10(-9), dominant model) with telangiectasia, 13q34 (rs3825460, P = 3.7 x 10(-8), dominant model) with size of pigmented spots on cheeks and 16p13.11(rs76053540, P = 5.0 x 10(-9), dominant model) with nasolabialfold. The signal on 15q21.1 was replicated in the meta-analysis with two independent Caucasian cohorts (P = 8.6 x 10(-10)). We have also successfully replicated in our cohort an association between SNP rs1048943 of gene CYP1A1 (P = 7.1 x 10(-4)) and pigmented spots on cheeks previously described in Caucasian cohort. Conclusions: Our study has identified new genetic risk factors for signs of skin aging in the Han Chinese. This study suggests there are differences in genetic susceptibility to skin aging between Caucasians and the Han Chinese. (C) 2019 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology. |
| 学科主题 | Cell Biology ; Immunology |
| WOS关键词 | AMYOTROPHIC-LATERAL-SCLEROSIS ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; ADAPTIVE IMMUNE-RESPONSES ; AMYLOID-BETA DEPOSITION ; CENTRAL-NERVOUS-SYSTEM ; MOTOR-NEURON DISEASE ; VERSUS-HOST-DISEASE ; BLOOD-BRAIN-BARRIER ; MOUSE MODEL ; ALZHEIMERS-DISEASE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31522824 |
| WOS记录号 | WOS:000497889600006 |
| 出版者 | ELSEVIER IRELAND LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/792]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Conservatoire Natl Arts & Metiers, Chaire Bioinformat, Labe Genom Bioinformat & Applicat, EA4627, Paris, France; 2.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn, Shanghai 200438, Peoples R China; 3.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Key Lab Contemporary Anthropol,Minist Educ, Shanghai 200438, Peoples R China; 4.Heinrich Heine Univ, Med Fac, Dusseldorf, Germany, 5.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth,CAS Key Lab Computat Bi, Shanghai Inst Biol Sci,CAS MPG Partner Inst Compu, Shanghai, Peoples R China; 6.IUF Leibniz Res Inst Environm Med, Aufm Hennekamp 50, D-40225 Dusseldorf, Germany; |
| 推荐引用方式 GB/T 7714 | Liu, Yu,Gao, Wenshan,Li, Bingjie,et al. Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2019,96(1):42-49. |
| APA | Liu, Yu.,Gao, Wenshan.,Li, Bingjie.,Peng, Qianqian.,Wu, Sijie.,...&,.(2019).Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.JOURNAL OF DERMATOLOGICAL SCIENCE,96(1),42-49. |
| MLA | Liu, Yu,et al."Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population".JOURNAL OF DERMATOLOGICAL SCIENCE 96.1(2019):42-49. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。