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Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785

文献类型：期刊论文

作者Adam, Jonathan5,6,7; Brandmaier, Stefan5,6,7; Troll, Martina5,6,7; Rotter, Markus5,6,7; Wang-Sattler, Rui5,6,7; Heier, Margit6; Adamski, Jerzy7; Neschen, Susanne7,10; Kastenmueller, Gabi7; Mohney, Robert P.8
刊名DIABETES
出版日期2017
卷号66期号:5页码:e3-e4
关键词breast cancer transformation epigenomics genome stability H3K9me3 transcription regulation
ISSN号0012-1797
DOI10.2337/dbi17-0010
文献子类Letter
英文摘要Aim: Epigenetic marks are critical regulators of chromatin and gene activity. Their roles in normal physiology and disease states, including cancer development, still remain elusive. Herein, the epigenomic change of H3K9me3, as well as its potential impacts on gene activity and genome stability, was investigated in an in vitro breast cancer transformation model. Methods: The global H3K9me3 level was studied with western blotting. The distribution of H3K9me3 on chromatin and gene expression was studied with ChIP-Seq and RNA-Seq, respectively. Results: The global H3K9me3 level decreases during transformation and its distribution on chromatin is reprogrammed. By combining with TCGA data, we identified 67 candidate oncogenes, among which five genes are totally novel. Our analysis further links H3K9me3 with transposon activity, and suggests H3K9me3 reduction increases the cell's sensitivity to DNA damage reagents. Conclusion: H3K9me3 reduction is possibly related with breast cancer transformation by regulating gene expression and chromatin stability during transformation.
学科主题Endocrinology & Metabolism
语种英语
WOS记录号WOS:000399799800002
出版者AMER DIABETES ASSOC
版本出版稿
源URL[http://202.127.25.144/handle/331004/794]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Tech Univ Munich, Lehrstuhl Math Modelle Biol Syst, Garching, Germany;
2.Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany;
3.Sanofi Deutschland GmbH, R&D Diabet Res & Translat Med, Frankfurt, Germany,
4.Tech Univ Munich, Inst Human Genet, Munich, Germany;
5.Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany;
6.Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany;
7.German Ctr Diabet Res DZD, Neuherberg, Germany;
8.Metabolon Inc, Durham, NC USA;
9.Helmholtz Zentrum Munchen, Inst Expt Genet, Genome Anal Ctr, Neuherberg, Germany;
10.Helmholtz Zentrum Munchen, Inst Expt Genet, Neuherberg, Germany;
推荐引用方式
GB/T 7714		 Adam, Jonathan,Brandmaier, Stefan,Troll, Martina,et al. Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785[J]. DIABETES,2017,66(5):e3-e4.
APA Adam, Jonathan.,Brandmaier, Stefan.,Troll, Martina.,Rotter, Markus.,Wang-Sattler, Rui.,...&,.(2017).Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785.DIABETES,66(5),e3-e4.
MLA Adam, Jonathan,et al."Response to Comment on Adam et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes 2016;65:3776-3785".DIABETES 66.5(2017):e3-e4.

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来源：上海营养与健康研究所

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