Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age
文献类型：期刊论文
| 作者 | Wu, Leilei2; Yao, Qianlan2; Li, Yixue2,3; Lin, Ping3; Feng, Fangyoumin3; Li, Hong3; Li, Yixue4; Pang, Shichao5; Jian, Chen1; Feng, Fangyoumin6 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:3471 |
| 关键词 | Histone deacetylase4 (HDAC4) Ischemia/reperfusion Myocardial function |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-02992-7 |
| 文献子类 | Article |
| 英文摘要 | Recent cancer researches pay more attention to younger patients due to the variable treatment response among different age groups. Here we investigated the effectiveness of neoadjuvant radiation on the survival of younger and older patients in stage II/III rectal cancer. Data was obtained from Surveillance, Epidemiology, and End Results (SEER) database (n = 12801). Propensity score matching was used to balance baseline covariates according to the status of neoadjuvant radiation. Our results showed that neoadjuvant radiation had better survival benefit (Log-rank P = 3.25e-06) and improved cancer-specific 3-year (87.6%; 95% CI: 86.4-88.7% vs. 84.1%; 95% CI: 82.8-85.3%) and 5-year survival rates (78.1%; 95% CI: 76.2-80.1% vs. 77%; 95% CI: 75.3-78.8%). In older groups (> 50), neoadjuvant radiation was associated with survival benefits in stage II (HR: 0.741; 95% CI: 0.599-0.916; P = 5.80e-3) and stage III (HR: 0.656; 95% CI 0.564-0.764; P = 5.26e-08). Interestingly, neoadjuvant radiation did not increase survival rate in younger patients (< = 50) both in stage II (HR: 2.014; 95% CI: 0.9032-4.490; P = 0.087) and stage III (HR: 1.168; 95% CI: 0.829-1.646; P = 0.372). Additionally, neoadjuvant radiation significantly decreased the cancer-specific mortality in older patients, but increased mortality in younger patients. Our results provided new insights on the neoadjuvant radiation in rectal cancer, especially for the younger patients. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | TOTAL MESORECTAL EXCISION ; PROPENSITY SCORE METHODS ; COLORECTAL-CANCER ; PREOPERATIVE RADIOTHERAPY ; POSTOPERATIVE CHEMORADIOTHERAPY ; MICROSATELLITE INSTABILITY ; LOCAL RECURRENCE ; ADJUVANT CHEMOTHERAPY ; RANDOMIZED-TRIAL ; YOUNG-PATIENTS |
| 语种 | 英语 |
| WOS记录号 | WOS:000403318400025 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/802]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gen Surg, Sch Med, Shanghai 201600, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China; 4.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Math Sci, Dept Stat, Shanghai 200240, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wu, Leilei,Yao, Qianlan,Li, Yixue,et al. Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age[J]. SCIENTIFIC REPORTS,2017,7(-):3471. |
| APA | Wu, Leilei.,Yao, Qianlan.,Li, Yixue.,Lin, Ping.,Feng, Fangyoumin.,...&,.(2017).Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age.SCIENTIFIC REPORTS,7(-),3471. |
| MLA | Wu, Leilei,et al."Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age".SCIENTIFIC REPORTS 7.-(2017):3471. |
入库方式： OAI收割
来源：上海营养与健康研究所
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