Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation
文献类型：期刊论文
| 作者 | He, Ke1; Hu, Jing1; Yu, Hongyao1; Wang, Lina1; Tang, Fan1; Gu, Junjie1; Ge, Laixiang1; Jin, Ying1; Jin, Ying3; Wang, Hongye2 |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2017 |
| 卷号 | 292期号:1页码:351-360 |
| 关键词 | acute myocardial infarction biomarkers non-coding RNAs circulating RNA cardiovascular diseases diagnosis prognosis |
| ISSN号 | 0021-9258 |
| DOI | 10.1074/jbc.M116.719849 |
| 文献子类 | Article |
| 英文摘要 | Skeletal muscle differentiation is a precisely coordinated process, and the molecular mechanism regulating the process remains incompletely understood. Here we report the identification of serine/threonine kinase 40 (Stk40) as a novel positive regulator of skeletal myoblast differentiation in culture and fetal skeletal muscle formation in vivo. We show that the expression level of Stk40 increases during skeletal muscle differentiation. Down-regulation and overexpression of Stk40 significantly decreases and increases myogenic differentiation of C2C12 myoblasts, respectively. In vivo, the number of myofibers and expression levels of myogenic markers are reduced in the fetal muscle of Stk40 knockout mice, indicating impaired fetal skeletal muscle formation. Mechanistically, Stk40 controls the protein level of histone deacetylase 5 (HDAC5) to maintain transcriptional activities of myocyte enhancer factor 2 (MEF2), a family of transcription factor important for skeletal myogenesis. Silencing of HDAC5 expression rescues the reduced myogenic gene expression caused by Stk40 deficiency. Together, our study reveals that Stk40 is required for fetal skeletal muscle development and provides molecular insights into the control of the HDAC5-MEF2 axis in skeletal myogenesis. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | MYOGENIC DIFFERENTIATION ; HISTONE DEACETYLASE-5 ; TRANSCRIPTION FACTOR ; MEF2 PROTEINS ; STEM-CELLS ; REGENERATION ; ENHANCER ; ROLES ; GENE ; ACTIVATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000391578000030 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/804]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Lab Mol Dev Biol, 280 South Chongqing Rd, Shanghai 200025, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200032, Peoples R China, 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol, Ctr Excellence Mol Cell Sci,Inst Hlth Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | He, Ke,Hu, Jing,Yu, Hongyao,et al. Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2017,292(1):351-360. |
| APA | He, Ke.,Hu, Jing.,Yu, Hongyao.,Wang, Lina.,Tang, Fan.,...&,.(2017).Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.JOURNAL OF BIOLOGICAL CHEMISTRY,292(1),351-360. |
| MLA | He, Ke,et al."Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation".JOURNAL OF BIOLOGICAL CHEMISTRY 292.1(2017):351-360. |
入库方式： OAI收割
来源：上海营养与健康研究所
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