The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network
文献类型：期刊论文
| 作者 | Jia, H.2,3,4; Song, L.2; Wang, J.2,4; Xu, H.2,4; Li, Q.2,4; Zhang, Y.2,4; Zou, X.2,4; Peng, H.2,3; Hou, Z.2,3,4; Chu, Y.3 |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2017 |
| 卷号 | 36期号:19页码:2655-2666 |
| 关键词 | gene flow Hui people population admixture Y chromosome |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/onc.2016.418 |
| 文献子类 | Article |
| 英文摘要 | The LIM protein AJUBA is a scaffold protein participating in the regulation of cell adhesion, mitosis, DNA damage, cell differentiation, proliferation, migration and gene transcription. However, its roles in tumorigenesis and progression are poorly defined. Here, we report that AJUBA is highly expressed in colorectal cancer (CRC) and promotes CRC cell growth in culture and in xenografted mice via an inhibition of apoptosis. AJUBA represses the expression of IFIT2 gene, an interferon-stimulated gene and a known apoptosis inducer and tumour suppressor to mediate its resistance to apoptosis. Mechanistic investigations reveal that AJUBA specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFN gamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC specimens is negatively correlated with the levels of IFIT2 and pSTAT1. Collectively, these studies demonstrate that AJUBA can promote CRC growth via inhibiting apoptosis and serve as a target for the therapeutics and a marker for diagnosis of CRC. |
| 学科主题 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| WOS关键词 | TRANSCRIPTIONAL REPRESSION ; EXPRESSION ; RECEPTOR ; PATHWAY ; FAMILY ; GAMMA ; SOCS ; LOCALIZATION ; MIGRATION ; ACTIVATOR |
| 语种 | 英语 |
| WOS记录号 | WOS:000401120900004 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/809]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis Chinese Min, Shanghai, Peoples R China, 2.Shanghai Jiao Tong Univ, Sch Med, Fac Basic Med, Hongqiao Inst Med,Shanghai Tongren Hosp, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Digest Endoscopy Ctr, 1111 Xianxia Rd, Shanghai 200336, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cellular Biol, Shanghai Key Lab Tumor Microenvironm & Inflammat, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Gen Surg, Shanghai 200011, Peoples R China; 6.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; 8.Dalian Med Univ, Canc Ctr, Inst Canc Stem Cells, Dalian, Liaoning, Peoples R China; 9.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jia, H.,Song, L.,Wang, J.,et al. The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network[J]. ONCOGENE,2017,36(19):2655-2666. |
| APA | Jia, H..,Song, L..,Wang, J..,Xu, H..,Li, Q..,...&,.(2017).The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network.ONCOGENE,36(19),2655-2666. |
| MLA | Jia, H.,et al."The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network".ONCOGENE 36.19(2017):2655-2666. |
入库方式： OAI收割
来源：上海营养与健康研究所
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