Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction
文献类型：期刊论文
| 作者 | Wang, Yong2; Lu, Linghui2; Wang, Wei2; Lin, Weili3; Li, Chun4; Singhal, Sarita5; Zhu, Lixin5; Jain, Gaurav6; Zhu, Lixin7,8; Zhu, Ruixin1 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:-页码:98 |
| 关键词 | Acute myocardial infarction Qishenyiqi anti-inflammation dyslipidaemia group significance analysis |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2017.00098 |
| 文献子类 | Article |
| 英文摘要 | Background: Based on global gene expression profile, therapeutic effects of Qishenyiqi (QSYQ) on acute myocardial infarction (AMI) were investigated by integrated analysis at multiple levels including gene expression, pathways involved and functional group. Methods: Sprague-Dawley (SD) rats were randomly divided into 3 groups: Sham-operated, AMI model (left anterior descending coronary artery ligation) and QSYQ-treated group. Cardiac tissues were obtained for analysing digital gene expression. Sequencing and transcriptome analyses were performed collaboratively, including analyses of differential gene expression, gene co-expression network, targeted attack on network and functional grouping. In this study, a new strategy known as keystone gene-based group significance analysis was also developed. Results: Analysis of top keystone QSYQ-regulated genes indicated that QSYQ ameliorated ventricular remodeling (VR), which is an irreversible process in the pathophysiology of AMI. At pathway level, both well-known cardiovascular diseases and cardiac signaling pathways were enriched. The most remarkable finding was the novel therapeutic effects identified from functional group analysis. This included anti-inflammatory effects mediated via suppression of arachidonic acid lipoxygenase (LOX) pathway and elevation of nitric oxide (NO); and amelioration of dyslipidaemia mediated via fatty acid oxidation. The regulatory patterns of QSYQ on key genes were confirmed by western blot, immunohistochemistry analysis and measurement of plasma lipids, which further validated the therapeutic effects of QSYQ proposed in this study. Conclusions: QSYQ exerts multipronged therapeutic effects on AMI, by concurrently alleviating VR progression, attenuating inflammation induced by arachidonic acid LOX pathway and NO production; and ameliorating dyslipidaemia. |
| 学科主题 | Pharmacology & Pharmacy |
| WOS关键词 | ARACHIDONIC-ACID METABOLISM ; HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; LIPOPROTEIN-LIPASE ; CHOLESTEROL ; EXPRESSION ; PLASMA ; RISK ; LEUKOTRIENES ; INFLAMMATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000395198400001 |
| 出版者 | FRONTIERS MEDIA SA |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/811]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tongji Univ, Sch Life Sci & Technol, Dept Bioinformat, Shanghai, Peoples R China, 2.Beijing Univ Chinese Med, Dept Biochem & Mol Biol, Basic Med Coll, Beijing, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China; 4.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China; 5.SUNY Buffalo, Dept Pediat, Digest Dis & Nutr Ctr, Buffalo, NY USA; 6.Niagara Falls Mem Med Ctr & Invis Hlth, Buffalo, NY USA; 7.SUNY Buffalo, Genome Environm & Microbiome Community Excellence, Buffalo, NY USA; 8.Shanghai Univ Tradit Chinese Med, Inst Digest Dis, Longhua Hosp, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Yong,Lu, Linghui,Wang, Wei,et al. Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction[J]. FRONTIERS IN PHARMACOLOGY,2017,8(-):98. |
| APA | Wang, Yong.,Lu, Linghui.,Wang, Wei.,Lin, Weili.,Li, Chun.,...&,.(2017).Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction.FRONTIERS IN PHARMACOLOGY,8(-),98. |
| MLA | Wang, Yong,et al."Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction".FRONTIERS IN PHARMACOLOGY 8.-(2017):98. |
入库方式： OAI收割
来源：上海营养与健康研究所
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