The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity
文献类型：期刊论文
| 作者 | Xiao, Yichuan3,5; Zou, Qiang4; Zou, Qiang5; Xie, Xiaoping5; Liu, Ting5; Li, Haiyan S.5; Jie, Zuliang5; Jin, Jin5; Hu, Hongbo2,5,8; Cheng, Xuhong5 |
| 刊名 | JOURNAL OF EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 214期号:5页码:1493-1507 |
| 关键词 | pulmonary hypertension biomarker miR-451 D-ECHO miRNAs |
| ISSN号 | 0022-1007 |
| DOI | 10.1084/jem.20161524 |
| 文献子类 | Article |
| 英文摘要 | Dendritic cells (DCs) are crucial for mediating immune responses but, when deregulated, also contribute to immunological disorders, such as autoimmunity. The molecular mechanism underlying the function of DCs is incompletely understood. In this study, we have identified TANK-binding kinase 1 (TBK1), a master innate immune kinase, as an important regulator of DC function. DC-specific deletion of Tbk1 causes T cell activation and autoimmune symptoms and also enhances antitumor immunity in animal models of cancer immunotherapy. The TBK1-deficient DCs have up-regulated expression of co-stimulatory molecules and increased T cell-priming activity. We further demonstrate that TBK1 negatively regulates the induction of a subset of genes by type I interferon receptor (IFNAR). Deletion of IFNAR1 could largely prevent aberrant T cell activation and autoimmunity in DC-conditional Tbk1 knockout mice. These findings identify a DC-specific function of TBK1 in the maintenance of immune homeostasis and tolerance. |
| 学科主题 | Immunology ; Research & Experimental Medicine |
| WOS关键词 | ANTIVIRAL RESPONSE ; TUMOR-IMMUNOTHERAPY ; VIRAL-INFECTION ; STAT3 ; ACTIVATION ; TOLERANCE ; LIPOPOLYSACCHARIDE ; RECOGNITION ; MATURATION ; SURVIVAL |
| 语种 | 英语 |
| WOS记录号 | WOS:000400379300020 |
| 出版者 | ROCKEFELLER UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/814]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.NYU, Sch Med, Dept Pathol, New York, NY 10016 USA; 2.Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China; 3.Chinese Acad Sci, Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Biol Sci,Inst Hlth Sci,Key Lab Stem, Shanghai 200031, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol,Chinese Minist Educ, Dept Immunol & Microbiol,Key Lab Cell Differentia, Shanghai 200025, Peoples R China; 5.Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA; 6.Univ Texas Houston, MD Anderson Canc Ctr, Grad Sch Biomed Sci, Houston, TX 77030 USA; 7.Univ Texas Houston, Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA; 8.Si Chuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; 9.Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China; 10.Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45220 USA; |
| 推荐引用方式 GB/T 7714 | Xiao, Yichuan,Zou, Qiang,Zou, Qiang,et al. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2017,214(5):1493-1507. |
| APA | Xiao, Yichuan.,Zou, Qiang.,Zou, Qiang.,Xie, Xiaoping.,Liu, Ting.,...&,.(2017).The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.JOURNAL OF EXPERIMENTAL MEDICINE,214(5),1493-1507. |
| MLA | Xiao, Yichuan,et al."The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity".JOURNAL OF EXPERIMENTAL MEDICINE 214.5(2017):1493-1507. |
入库方式： OAI收割
来源：上海营养与健康研究所
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