SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
文献类型：期刊论文
| 作者 | Luo, Chunling2; Cheng, Yuanming2; Liu, Yuguo2; Chen, Linlin2; Liu, Lina2; Wei, Ning2; Xie, Zhiqin2; Wu, Wenwu2; Feng, Ying2; Wu, Wenwu1 |
| 刊名 | CANCER RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 77期号:5页码:1168-1178 |
| 关键词 | Fatty acid-binding protein 4 hepatocellular carcinoma poor prognosis proliferation and invasion |
| ISSN号 | 0008-5472 |
| DOI | 10.1158/0008-5472.CAN-16-1919 |
| 文献子类 | Article |
| 英文摘要 | Aberrant RNA splicing is recognized to contribute to cancer pathogenesis, but the underlying mechanisms remain mainly obscure. Here, we report that the splicing factor SRSF2 is upregulated frequently in human hepatocellular carcinoma (HCC), where this event is associated with poor prognosis in patients. RNA-seq and other molecular analyses were used to identify SRSF2-regulated alternative splicing events. SRSF2 binding within an alternative exon was associated with its inclusion in the RNA, whereas SRSF2 binding in a flanking constitutive exon was associated with exclusion of the alternative exon. Notably, cancer-associated splice variants upregulated by SRSF2 in clinical specimens of HCC were found to be crucial for pathogenesis and progression in hepatoma cells, where SRSF2 expression increased cell proliferation and tumorigenic potential by controlling expression of these variants. Our findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC. (C) 2017 AACR. |
| 学科主题 | Oncology |
| WOS关键词 | SR PROTEINS ; CANCER ; RNA ; REVEALS ; EVENTS ; DIFFERENTIATION ; MYELODYSPLASIA ; TRANSCRIPTOME ; METASTASIS ; MECHANISMS |
| 语种 | 英语 |
| WOS记录号 | WOS:000396011100012 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/815]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Zhejiang Agr & Forestry Univ, State Key Lab Subtrop Silviculture, Nurturing Stn, Linan, Peoples R China, 2.Chinese Acad Sci, Inst Nutr Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Luo, Chunling,Cheng, Yuanming,Liu, Yuguo,et al. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development[J]. CANCER RESEARCH,2017,77(5):1168-1178. |
| APA | Luo, Chunling.,Cheng, Yuanming.,Liu, Yuguo.,Chen, Linlin.,Liu, Lina.,...&,.(2017).SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development.CANCER RESEARCH,77(5),1168-1178. |
| MLA | Luo, Chunling,et al."SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development".CANCER RESEARCH 77.5(2017):1168-1178. |
入库方式： OAI收割
来源：上海营养与健康研究所
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