Comparative genetic architectures of schizophrenia in East Asian and European populations
文献类型：期刊论文
| 作者 | Lam, Max1,2,3,4,26,27; Shi, Yongyong2,3,31,32,33,34; Liu, Jianjun4; Chen, Chia-Yen26,27; Martin, Alicia R.26,27,28; Liu, Ruize26,27; Neale, Benjamin M.26,27,28; Ripke, Stephan26,27; Daly, Mark J.26,27,28; Huang, Hailiang26,27,28 |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2019 |
| 卷号 | 51期号:12页码:1670+ |
| ISSN号 | 1061-4036 |
| 关键词 | prolyl hydroxylase intestinal epithelium homeostasis |
| DOI | 10.1038/s41588-019-0512-x |
| 文献子类 | Article |
| 英文摘要 | Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 +/- 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; POLYGENIC RISK SCORES ; INFLAMMATORY-BOWEL-DISEASE ; 38 SUSCEPTIBILITY LOCI ; GENOTYPE IMPUTATION ; COMMON VARIANTS ; HAN CHINESE ; METAANALYSIS ; INDIVIDUALS ; SELECTION |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31740837 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000499696700004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/820]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Northwell Hlth, Div Psychiat Res, Zucker Hillside Hosp, Glen Oaks, NY USA; 2.Shanghai Jiao Tong Univ, Bio X Inst, Shanghai, Peoples R China; 3.Inst Mental Hlth Singapore, Res Div, Singapore, Singapore; 4.Genome Inst Singapore, Human Genet, Singapore, Singapore; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China; 7.Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China; 8.Univ North Carolina Chapel Hill, Dept Genet, Chapel Hill, NC USA; 9.Charite, Dept Psychiat & Psychotherapy, Berlin, Germany; 10.Inst Mol Med Finland FIMM, Helsinki, Finland; |
| 推荐引用方式 GB/T 7714 | Lam, Max,Shi, Yongyong,Liu, Jianjun,et al. Comparative genetic architectures of schizophrenia in East Asian and European populations[J]. NATURE GENETICS,2019,51(12):1670+. |
| APA | Lam, Max.,Shi, Yongyong.,Liu, Jianjun.,Chen, Chia-Yen.,Martin, Alicia R..,...&,.(2019).Comparative genetic architectures of schizophrenia in East Asian and European populations.NATURE GENETICS,51(12),1670+. |
| MLA | Lam, Max,et al."Comparative genetic architectures of schizophrenia in East Asian and European populations".NATURE GENETICS 51.12(2019):1670+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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