Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26
文献类型：期刊论文
| 作者 | Sun, Hongwei5; Kong, Hongru5; Zhang, Jie5; Dai, Shengjie5; Ye, Wen5; Deng, Tuo5; Shi, Keqing4; Qi, Kai3; He, Qiye1,2; Zhou, Mengtao6 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:-页码:2819 |
| 关键词 | natural killer pancreatic cancer extracellular vesicles miR-3607-3p IL-26 |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2019.02819 |
| 文献子类 | Article |
| 英文摘要 | Increasing evidences have suggested that natural killer (NK) cells in the tumor microenvironment are involved in the regulation of cancer development. However, the potential biological roles and regulatory mechanisms of NK cells in pancreatic cancer (PC) remain unclear. Co-culture system of NK cells with PC cells is used to test the ability of cancer cell proliferation, migration and invasion both in vitro and in vivo. And tail vein intravenous transfer was used to test metastasis in vivo. Meanwhile, extracellular vesicles (EVs) were separated and examined. Furthermore, reporter assay and Biotin-RNA pull down assay were performed to verify the interaction between molecules. NK cells can inhibit the malignant transformation of co-cultured PC cells both in vivo and in vitro, which requires miR-3607-3p. miR-3607-3p is found enriched in the EVs of NK cells and transmitted to PC cells, and low level of miR-3607-3p predicts poor prognosis in PC patients. It can also inhibit proliferation, migration and invasion of PC cells in vitro. Importantly, IL-26 is found to be a direct target of miR-3607-3p in PC cells. miR-3607-3p enriched in EVs derived from NK cells can inhibit the malignant transformation of PC probably through directly targeting of IL-26. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | EXTRACELLULAR VESICLES ; TUMOR MICROENVIRONMENT ; NK CELLS |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31921112 |
| WOS记录号 | WOS:000504227600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/821]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Singlera Genom Shanghai Ltd, Shanghai, Peoples R China; 2.Singlera Genom Inc, San Diego, CA USA; 3.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China; 4.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Ctr Precis Med, Affiliated Hosp 1, Wenzhou, Peoples R China; 5.Wenzhou Med Univ, Dept Hepatobiliery Surg, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou, Peoples R China; 6.Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Precis Med Ctr Lab, Affiliated Hosp 1, Wenzhou, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Sun, Hongwei,Kong, Hongru,Zhang, Jie,et al. Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26[J]. FRONTIERS IN IMMUNOLOGY,2019,10(-):2819. |
| APA | Sun, Hongwei.,Kong, Hongru.,Zhang, Jie.,Dai, Shengjie.,Ye, Wen.,...&,.(2019).Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26.FRONTIERS IN IMMUNOLOGY,10(-),2819. |
| MLA | Sun, Hongwei,et al."Natural Killer Cell-Derived Exosomal miR-3607-3p Inhibits Pancreatic Cancer Progression by Targeting IL-26".FRONTIERS IN IMMUNOLOGY 10.-(2019):2819. |
入库方式： OAI收割
来源：上海营养与健康研究所
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