Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems
文献类型：期刊论文
| 作者 | Guo Fucheng1; He Jing1; Hai Le1; Ming Liang1; Yi Li1; Ji Rimutu1,3; Si Rendalai3; Yuan Liyun2; , |
| 刊名 | LIVESTOCK SCIENCE
 |
| 出版日期 | 2019 |
| 卷号 | 228期号:-页码:195-200 |
| 关键词 | Camelus bactrianus Hump Transcriptome Survival |
| ISSN号 | 1871-1413 |
| DOI | 10.1016/j.livsci.2019.09.003 |
| 文献子类 | Article |
| 英文摘要 | The unique hump structure of the Bactrian camel has helped it adapt to the harsh desert environment, and the adipose tissue contained in the hump is believed to play important roles in its survival. We used RNA sequencing to examine the transcriptome profiles of 7 adipose tissues of the fore hump, hind hump, subcutaneous, intermuscular, perihepatic, pericardial and peripheral tissues. A total of 4191 differentially expressed genes (DEGs) were identified between visceral fat (VF) and hump fat combined with subcutaneous fat (HS). Additionally, DEGs were also identified in the fore hump (FH), hind hump (HH) and subcutaneous fat (SC). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the identified DEGs showed that the hump has specialized immune and endocrine functions, in addition to its osmoregulatory roles. Further, DEGs involved in human diseases were significantly upregulated in visceral fat (VF), and DEGs associated with anti-hypertensive and anti-diabetic mechanisms were upregulated in HS. So HS seems to be more beneficial to health than visceral fat. Besides, fore hump has more immune and endocrine diverse genetic profile than subcutaneous fat. Thus, fore hump may be important for Bactrian camel's survival. Additional adaptation mechanisms should be further explored by obtaining more information on genetic and molecular mechanisms involved. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS关键词 | GENE |
| 语种 | 英语 |
| WOS记录号 | WOS:000491604300028 |
| 出版者 | ELSEVIER |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/828]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Key Lab Dairy Biotechnol & Bioengn, Minist Educ, 306 Zhao Wu Rd, Hohhot 010018, Inner Mongolia, Peoples R China; 2.Chinese Acad Sci, Biomed Big Data Ctr, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China, 3.Camel Res Inst Inner Mongolia, Alashan 737300, Inner Mongolia, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Guo Fucheng,He Jing,Hai Le,et al. Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems[J]. LIVESTOCK SCIENCE,2019,228(-):195-200. |
| APA | Guo Fucheng.,He Jing.,Hai Le.,Ming Liang.,Yi Li.,...&,.(2019).Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems.LIVESTOCK SCIENCE,228(-),195-200. |
| MLA | Guo Fucheng,et al."Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems".LIVESTOCK SCIENCE 228.-(2019):195-200. |
入库方式： OAI收割
来源：上海营养与健康研究所
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