Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway
文献类型：期刊论文
| 作者 | Xu, Mafei2; Wang, Leiming2; Kao, Chung-Yang2; Tsai, Ming-Jer2; Tsai, Sophia Y.2,8; Qin, Jun3; Lee, Hui-Ju4; Liu, Dan5; Zhou Songyang5; Zhou Songyang6,7 |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2019 |
| 卷号 | 5期号:10页码:eaax6366 |
| 关键词 | microRNA sponge young noncoding RNA co-evolution tumorigenesis |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.aax6366 |
| 文献子类 | Article |
| 英文摘要 | Alternative lengthening of telomeres (2ALT) is known to use homologous recombination (HR) to replicate telomeric DNA in a telomerase-independent manner. However, the detailed process remains largely undefined. It was reported that nuclear receptors COUP-TFII and TR4 are recruited to the enriched GGGTCA variant repeats embedded within ALT telomeres, implicating nuclear receptors in regulating ALT activity. Here, we identified a function of nuclear receptors in ALT telomere maintenance that involves a direct interaction between COUP-TFII/TR4 and FANCD2, the key protein in the Fanconi anemia (FA) DNA repair pathway. The COUP-TFII/TR4-FANCD2 complex actively induces the DNA damage response by recruiting endonuclease MUS81 and promoting the loading of the PCNA-POLD3 replication complex in ALT telomeres. Furthermore, the COUP-TFII/TR4-mediated ALT telomere pathway does not require the FA core complex or the monoubiquitylation of FANCD2, key steps in the canonical FA pathway. Thus, our findings reveal that COUP-TFII/TR4 regulates ALT telomere maintenance through a novel noncanonical FANCD2 pathway. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| WOS关键词 | FANCONI-ANEMIA PATHWAY ; MONOUBIQUITINATED FANCD2 ; CROSS-LINKS ; INTERSTRAND ; TRANSCRIPTION ; INSTABILITY ; CHROMATIN ; GROWTH ; CANCER ; ORPHAN |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31633027 |
| WOS记录号 | WOS:000491132700052 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/829]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA; 2.Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Tissue Microenvironm & Tumor, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Nut, Shanghai, Peoples R China; 4.Houston Methodist Res Inst, Ctr Immunotherapy Res, Houston, TX USA; 5.Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA; 6.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China; 7.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China; 8.Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA, |
| 推荐引用方式 GB/T 7714 | Xu, Mafei,Wang, Leiming,Kao, Chung-Yang,et al. Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway[J]. SCIENCE ADVANCES,2019,5(10):eaax6366. |
| APA | Xu, Mafei.,Wang, Leiming.,Kao, Chung-Yang.,Tsai, Ming-Jer.,Tsai, Sophia Y..,...&,.(2019).Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway.SCIENCE ADVANCES,5(10),eaax6366. |
| MLA | Xu, Mafei,et al."Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway".SCIENCE ADVANCES 5.10(2019):eaax6366. |
入库方式： OAI收割
来源：上海营养与健康研究所
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