eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses
文献类型：期刊论文
| 作者 | Yu, Dalang2,5; Yan, Fangqi5; Mu, Hailong5; Gao, Feng5; Hao, Ziqian2,5; Huang, Hongwei5; Wei, Yuzhang5; Pan, Wei5; Wang, Pengyu5; Li, Mushan5 |
| 刊名 | NATIONAL SCIENCE REVIEW
 |
| 出版日期 | 2019 |
| 卷号 | 6期号:5页码:867-869 |
| 关键词 | FAM122A SUMO1 modification PP2A Ubiquitination Phosphatase activity |
| ISSN号 | 2095-5138 |
| DOI | 10.1093/nsr/nwz079 |
| 文献子类 | Editorial Material |
| 英文摘要 | All haematopoietic cell lineages that circulate in the blood of adult mammals derive from multipotent haematopoietic stem cells (HSCs) 1. By contrast, in the blood of mammalian embryos, lineage-restricted progenitors arise first, independently of HSCs, which only emerge later in gestation2,3. As best defined in the mouse, 'primitive' progenitors first appear in the yolk sac at 7.5 days post-coitum2,3. Subsequently, erythroid-myeloid progenitors that express fetal haemoglobin4, as well as fetal lymphoid progenitors5, develop in the yolk sac and the embryo proper, but these cells lack HSC potential. Ultimately, 'definitive' HSCs with long-term, multilineage potential and the ability to engraft irradiated adults emerge at 10.5 days post-coitum from arterial endothelium in the aorta-gonad-mesonephros and other haemogenic vasculature3. The molecular mechanisms of this reverse progression of haematopoietic ontogeny remain unexplained. We hypothesized that the definitive haematopoietic program might be actively repressed in early embryogenesis through epigenetic silencing6, and that alleviating this repression would elicit multipotency in otherwise lineage-restricted haematopoietic progenitors. Here we show that reduced expression of the Polycomb group protein EZH1 enhances multi-lymphoid output from human pluripotent stem cells. In addition, Ezh1 deficiency in mouse embryos results in precocious emergence of functional definitive HSCs in vivo. Thus, we identify EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | PLURIPOTENT STEM-CELLS ; MOUSE EMBRYO ; DEFINED FACTORS ; BLOOD-CELLS ; CHROMATIN ; LINEAGE ; ENDOTHELIUM ; PROGENITORS ; RESISTANCE ; LEUKEMIA |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31921812 |
| WOS记录号 | WOS:000512966500008 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/832]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Beijing, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China, 3.Shanghai Res Ctr Brain Sci & Brain Inspired Intel, Shanghai, Peoples R China; 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Beijing, Peoples R China; 5.Chinese Acad Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol,Univ Chinese A, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Beijing, Peoples R China; 6.Chinese Acad Sci, Beijing Inst Genom, BIG Data Ctr, Beijing, Peoples R China; 7.Chinese Acad Sci, Beijing Inst Life Sci, Computat Genom Lab, Beijing, Peoples R China; 8.Chinese Acad Sci, Beijing Inst Genom, CAS Lab Genom & Precis Med, Beijing, Peoples R China; 9.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China; 10.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Key Lab Syst Biol, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yu, Dalang,Yan, Fangqi,Mu, Hailong,et al. eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses[J]. NATIONAL SCIENCE REVIEW,2019,6(5):867-869. |
| APA | Yu, Dalang.,Yan, Fangqi.,Mu, Hailong.,Gao, Feng.,Hao, Ziqian.,...&,.(2019).eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses.NATIONAL SCIENCE REVIEW,6(5),867-869. |
| MLA | Yu, Dalang,et al."eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses".NATIONAL SCIENCE REVIEW 6.5(2019):867-869. |
入库方式： OAI收割
来源：上海营养与健康研究所
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