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Revisiting ovarian cancer microenvironment: a friend or a foe?

文献类型：期刊论文

作者Zhang, Boyi2,3; Chen, Fei2,3; Han, Liu2,3; Gao, Libin2,3; Sun, Xiaochen2,3; Li, Yiwen2,3; Li, Yan2,3; Qian, Min2,3; Sun, Yu2,3; Xu, Qixia4,5
刊名PROTEIN & CELL
出版日期2018
卷号9期号:8页码:674-692
关键词ovarian cancer stromal cells tumor microenvironment therapeutic resistance ectopic metastasis combinational treatment patient stratification
ISSN号1674-800X
DOI10.1007/s13238-017-0466-7
文献子类Review
英文摘要Development of ovarian cancer involves the co-evolution of neoplastic cells together with the adjacent microenvironment. Steps of malignant progression including primary tumor outgrowth, therapeutic resistance, and distant metastasis are not determined solely by genetic alterations in ovarian cancer cells, but considerably shaped by the fitness advantage conferred by benign components in the ovarian stroma. As the dynamic cancer topography varies drastically during disease progression, heterologous cell types within the tumor microenvironment (TME) can actively determine the pathological track of ovarian cancer. Resembling many other solid tumor types, ovarian malignancy is nurtured by a TME whose dark side may have been overlooked, rather than overestimated. Further, harnessing breakthrough and targeting cures in human ovarian cancer requires insightful understanding of the merits and drawbacks of current treatment modalities, which mainly target transformed cells. Thus, designing novel and precise strategies that both eliminate cancer cells and manipulate the TME is increasingly recognized as a rational avenue to improve therapeutic outcome and prevent disease deterioration of ovarian cancer patients.
学科主题Cell Biology
WOS关键词MESENCHYMAL STEM-CELLS ; TUMOR-INFILTRATING LYMPHOCYTES ; GRADE-SEROUS-CARCINOMA ; REGULATORY T-CELLS ; STROMAL CELLS ; ADIPOSE-TISSUE ; MICRORNA SIGNATURES ; CELLULAR SENESCENCE ; PANCREATIC-CANCER ; MEMBRANE-VESICLES
语种英语
CSCD记录号CSCD:31771308
WOS记录号WOS:000439494500002
出版者SPRINGEROPEN
版本出版稿
源URL[http://202.127.25.144/handle/331004/836]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Washington, Dept Med, Seattle, WA 98195 USA;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China;
3.Shanghai Jiao Tong Univ, Sch Med, Univ Chinese Acad Sci, Shanghai 200031, Peoples R China;
4.Shanghai Jiao Tong Univ, Inst Hlth Sci, Sch Med, Shanghai 200031, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
6.Univ Washington, VAPSHCS, Seattle, WA 98195 USA,
推荐引用方式
GB/T 7714		 Zhang, Boyi,Chen, Fei,Han, Liu,et al. Revisiting ovarian cancer microenvironment: a friend or a foe?[J]. PROTEIN & CELL,2018,9(8):674-692.
APA Zhang, Boyi.,Chen, Fei.,Han, Liu.,Gao, Libin.,Sun, Xiaochen.,...&,.(2018).Revisiting ovarian cancer microenvironment: a friend or a foe?.PROTEIN & CELL,9(8),674-692.
MLA Zhang, Boyi,et al."Revisiting ovarian cancer microenvironment: a friend or a foe?".PROTEIN & CELL 9.8(2018):674-692.

入库方式： OAI收割

来源：上海营养与健康研究所

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