Metabolome signature of autism in the human prefrontal cortex
文献类型：期刊论文
| 作者 | Kurochkin, Ilia5; Khrameeva, Ekaterina5; Tkachev, Anna5,6; Stepanova, Vita5,6; Vanyushkina, Anna5; Stekolshchikova, Elena5; Zubkov, Dmitry5; Shichkova, Polina5; Khaitovich, Philipp5,7; Khrameeva, Ekaterina6 |
| 刊名 | COMMUNICATIONS BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 2期号:-页码:234 |
| 关键词 | epigenetics environment cancer molecular mechanisms research gaps perspectives biomarkers |
| ISSN号 | 0020-7136 |
| DOI | 10.1038/s42003-019-0485-4 |
| 文献子类 | Article |
| 英文摘要 | Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p < 0.05), opening an opportunity for the design of new diagnostic instruments. Furthermore, metabolic measurements conducted in 40 chimpanzees and 40 macaques showed an excess of metabolite intensity differences unique to humans, supporting the hypothesized disruption of evolutionary novel cortical mechanisms in ASD. |
| 学科主题 | Oncology |
| WOS关键词 | CHILDREN POPULATION ; SPECTRUM DISORDERS ; OXIDATIVE STRESS ; BIOMARKERS ; HERITABILITY ; GLUTATHIONE ; EVOLUTION ; PATHWAYS ; H-1-NMR ; PROFILE |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31921112 |
| WOS记录号 | WOS:000472611700005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/840]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA; 2.Max Planck Inst Mol Plant Physiol, Muhlenberg 1, D-14476 Potsdam, Germany; 3.Max Planck Inst Evolutionary Anthropol, Deutsch Pl 6, D-04103 Leipzig, Germany, 4.Max Planck Inst Biol Ageing, D-50931 Cologne, Germany; 5.Skolkovo Inst Sci & Technol, Ctr Neurobiol & Brain Restorat, Moscow 121205, Russia; 6.Russian Acad Sci, Inst Informat Transmiss Problems, Bolshoy Karetny Per 19-1, Moscow 127051, Russia; 7.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 8.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA; |
| 推荐引用方式 GB/T 7714 | Kurochkin, Ilia,Khrameeva, Ekaterina,Tkachev, Anna,et al. Metabolome signature of autism in the human prefrontal cortex[J]. COMMUNICATIONS BIOLOGY,2019,2(-):234. |
| APA | Kurochkin, Ilia.,Khrameeva, Ekaterina.,Tkachev, Anna.,Stepanova, Vita.,Vanyushkina, Anna.,...&,.(2019).Metabolome signature of autism in the human prefrontal cortex.COMMUNICATIONS BIOLOGY,2(-),234. |
| MLA | Kurochkin, Ilia,et al."Metabolome signature of autism in the human prefrontal cortex".COMMUNICATIONS BIOLOGY 2.-(2019):234. |
入库方式： OAI收割
来源：上海营养与健康研究所
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