FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis
文献类型：期刊论文
| 作者 | Zhan, Rui1,2,3,4; Gao, Yuan1,2,3; Zhao, Xiaotong1,2,3,4; Gao, Mei1,2,3; Wu, Yanjun1,2,3; Han, Yingying1,2,3,4; Qiao, Yuemei1,2,3; Chen, Jianfeng1,4; Ge, Gaoxiang1,2,3,4; Luo, Zheng4 |
| 刊名 | PLOS BIOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:8页码:e2001493 |
| 关键词 | acute myocardial infarction biomarkers non-coding RNAs circulating RNA cardiovascular diseases diagnosis prognosis |
| ISSN号 | 1545-7885 |
| DOI | 10.1371/journal.pbio.2001493 |
| 文献子类 | Article |
| 英文摘要 | Adipocyte progenitors reside in the stromal vascular fraction (SVF) of adipose tissues that are composed of fibroblasts, immune cells, and endothelial cells. It remains to be elucidated how the SVF regulates adipocyte progenitor fate determination and adipose homeostasis. Here, we report that fibroblast-specific protein-1 (FSP1)(+) fibroblasts in the SVF are essential to adipose homeostasis. FSP1(+) fibroblasts, devoid of adipogenic potential, are adjacent to the preadipocytes in the SVF. Ablation of FSP1(+) fibroblasts in mice severely diminishes fat content of adipose depots. Activation of canonical Wnt signaling in the FSP1(+) fibroblasts results in gradual loss of adipose tissues and resistance to diet-induced obesity. Alterations in the FSP1(+) fibroblasts reduce platelet-derived growth factor (PDGF)-BB signaling and result in the loss of preadipocytes. Reduced PDGF-BB signaling, meanwhile, impairs the adipogenic differentiation capability of preadipocytes by regulating matrix metalloproteinase (MMP) expression, extracellular matrix remodeling, and the activation of Yes-associated protein (YAP) signaling. Thus, FSP1(+) fibroblasts are an important niche essential to the maintenance of the preadipocyte pool and its adipogenic potential in adipose homeostasis. |
| 学科主题 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| WOS关键词 | MATRIX METALLOPROTEINASES ; ADIPOCYTE DIFFERENTIATION ; INSULIN-RESISTANCE ; IN-VIVO ; TISSUE ; CANCER ; WHITE ; FAT ; OBESITY ; CELLS |
| 语种 | 英语 |
| WOS记录号 | WOS:000443383300001 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/844]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, CAS Key Lab Syst Biol, Shanghai, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; 5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhan, Rui,Gao, Yuan,Zhao, Xiaotong,et al. FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis[J]. PLOS BIOLOGY,2018,16(8):e2001493. |
| APA | Zhan, Rui.,Gao, Yuan.,Zhao, Xiaotong.,Gao, Mei.,Wu, Yanjun.,...&,.(2018).FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis.PLOS BIOLOGY,16(8),e2001493. |
| MLA | Zhan, Rui,et al."FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis".PLOS BIOLOGY 16.8(2018):e2001493. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。