Genetic lineage tracing analysis of c-kit(+) stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions
文献类型：期刊论文
| 作者 | Chen, Qishan2; Yang, Mei2; Wu, Hong2; Wang, Weina2; Zhu, Jianhua2; Zhang, Li2; Zhou, Jiaojiao3; Zhang, Hongkun4; Zhao, Lin1; Zhou, Bin5 |
| 刊名 | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 121期号:-页码:277-286 |
| ISSN号 | 0022-2828 |
| 关键词 | Cell lineage tracing C-kit(+) progenitor Endothelial cell Smooth muscle cell Myeloid cell Neointma formation |
| DOI | 10.1016/j.yjmcc.2018.07.252 |
| 文献子类 | Article |
| 英文摘要 | Aims: Accumulating evidence indicates the presence of vascular stem/progenitor cells that may play a role in endothelial repair and lesion formation in the injured artery, in which c-kit(+) stem/progenitor cells have been reported to differentiate into endothelial and smooth muscle cells in vitro and in ischemic tissue. In this study, we investigated whether and how endogenous c-kit(+) stem/progenitor cells contribute to vascular injury and neointima formation in vivo. Methods and results: We created Kit-CreERxRosa26-RFP mice and performed genetic lineage tracing analysis of c-kit(+) stem/progenitor cells in injury-induced neointima formation in vivo. We provide direct evidence that endogenous c-kit(+) stem/progenitor cells minimally differentiate into endothelial or smooth muscle cells facilitating vascular repair, but predominantly generate monocytes/macrophages and granulocytes contributing to vascular immuno-inflammatory response to endothelial injury. Although c-kit(+) cells reside in both bone marrow and vessel wall, bone marrow transplantation data indicate that bone marrow-derived c-kit(+) cells are the main source for enhancing neointima formation. Furthermore, treatment of ACK2, a c-kit receptor antagonizer, attenuates neointimal hyperplasia after injury at least in part by depleting c-kit(+) cells and their generated progeny. Conclusions: c-kit(+) stem/progenitor cells are not a main source for endothelial regeneration and smooth muscle accumulation of the large artery injury, but a plausible interventional approach to reduce vascular immuno-inflammatory response and subsequently to ameliorate vascular lesions. |
| 学科主题 | Cardiovascular System & Cardiology ; Cell Biology |
| WOS关键词 | HEMATOPOIETIC PROGENITOR CELLS ; MARROW-DERIVED CELLS ; CARDIAC STEM-CELLS ; INTIMAL HYPERPLASIA ; IMATINIB MESYLATE ; C-KIT ; ATHEROSCLEROSIS ; INFLAMMATION ; REPAIR ; REGENERATION |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000443763300029 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/846]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China; 2.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China; 3.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg Oncol, Hangzhou, Zhejiang, Peoples R China; 4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Vasc Surg, Hangzhou, Zhejiang, Peoples R China; 5.Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci,Grad Sch, Shanghai, Peoples R China; 6.Kings Coll London, Cardiovasc Div, British Heart Fdn Ctr, 125 Coldharbour Lane, London SE5 9NU, England, |
| 推荐引用方式 GB/T 7714 | Chen, Qishan,Yang, Mei,Wu, Hong,et al. Genetic lineage tracing analysis of c-kit(+) stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,2018,121(-):277-286. |
| APA | Chen, Qishan.,Yang, Mei.,Wu, Hong.,Wang, Weina.,Zhu, Jianhua.,...&,.(2018).Genetic lineage tracing analysis of c-kit(+) stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions.JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,121(-),277-286. |
| MLA | Chen, Qishan,et al."Genetic lineage tracing analysis of c-kit(+) stem/progenitor cells revealed a contribution to vascular injury-induced neointimal lesions".JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 121.-(2018):277-286. |
入库方式： OAI收割
来源：上海营养与健康研究所
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