IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice
文献类型：期刊论文
| 作者 | Wu, Rui2; Yin, Jianyong2; Wang, Niansong2; Liu, Xuanchen3; Wang, Feng3; Wu, Huijuan4; Cai, Xiulei5; Qian, Youcun1,6; , |
| 刊名 | METABOLISM-CLINICAL AND EXPERIMENTAL
 |
| 出版日期 | 2018 |
| 卷号 | 83期号:-页码:18-24 |
| 关键词 | IL-6 Tocilizumab Inflammation NLRP3 inflammasome IL-17A Biologics |
| ISSN号 | 0026-0495 |
| DOI | 10.1016/j.metabol.2018.01.002 |
| 文献子类 | Article |
| 英文摘要 | Background and Objective: Interleukin 6 (IL-6) has been identified as a key mediator in inflammation, immune responses and glucose metabolism. In this study, we assessed the effects of an IL-6 receptor antibody on diabetic nephropathy in a mouse model of type 2 diabetes mellitus. Methods: Twelve week old male db/db mice were treated with Tocilizumab (an IL-6 receptor antibody), normal IgG1 control antibody, insulin or normal saline for 12 weeks. Renal injury, inflammation and insulin resistance were assessed. Results: Db/db mice treated with Tocilizumab exhibited reduced proteinuria and glomerular mesangial matrix accumulation compared to db/db + IgG controls. Additionally, Tocilizumab suppressed inflammatory response, oxidative stress and the IL-6 signaling pathway in the diabetic kidneys. It is noteworthy that blockade of IL-6 receptor blunted the activation of NLRP3 inflammasome partly through inhibition of IL-17A. Furthermore, insulin resistance assessed by glucose tolerance test, was ameliorated by Tocilizumab treatment. Conclusions: The protective effects of an IL-6 receptor blockade against diabetic renal injury may be due to decreased insulin resistance and inhibition of the inflammasome. (C) 2018 Elsevier Inc. All rights reserved. |
| 学科主题 | Endocrinology & Metabolism |
| WOS关键词 | SYSTEMIC INSULIN-RESISTANCE ; NLRP3 INFLAMMASOME ; HEPATIC INFLAMMATION ; MESANGIAL CELLS ; LUNG INJURY ; DB/DB MICE ; INTERLEUKIN-6 ; PATHOGENESIS ; ACTIVATION ; HYPERTENSION |
| 语种 | 英语 |
| WOS记录号 | WOS:000442835700005 |
| 出版者 | W B SAUNDERS CO-ELSEVIER INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/847]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China, 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Nephrol, Shanghai 200233, Peoples R China; 3.Shanghai Jiao Tong Univ, Jiangsu Univ, Affiliated Peoples Hosp 6, Affiliated Shanghai Peoples Hosp 8,Dept Nephrol, Shanghai 200233, Peoples R China; 4.Fudan Univ, Shanghai Med Coll, Dept Pathol, Shanghai 200032, Peoples R China; 5.Qingdao Agr Univ, Coll Vet Med, Qingdao 266109, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol,CAS Ctr Excellence Mol Cel, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Rui,Yin, Jianyong,Wang, Niansong,et al. IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2018,83(-):18-24. |
| APA | Wu, Rui.,Yin, Jianyong.,Wang, Niansong.,Liu, Xuanchen.,Wang, Feng.,...&,.(2018).IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice.METABOLISM-CLINICAL AND EXPERIMENTAL,83(-),18-24. |
| MLA | Wu, Rui,et al."IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice".METABOLISM-CLINICAL AND EXPERIMENTAL 83.-(2018):18-24. |
入库方式： OAI收割
来源：上海营养与健康研究所
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