Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method
文献类型：期刊论文
| 作者 | Ren, Weiquan1; Zhang, Huimin1; Ren, Yinglu1; Yu, Xue1; Guo, Shuzhen1; Wang, Wei1; Gao, Sheng2; Zhu, Ruixin2; Lin, Weili3,4; , |
| 刊名 | MOLECULES
 |
| 出版日期 | 2018 |
| 卷号 | 23期号:7页码:1829 |
| 关键词 | Qishen granules heart failure quantitative pathway analysis decomposing formula Wenyang Yiqi Huoxue Qingre Jiedu |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules23071829 |
| 文献子类 | Article |
| 英文摘要 | Qishen granules (QSG) have beneficial therapeutic effects for heart failure, but the effects of decomposed recipes, including Wenyang Yiqi Huoxue (WYH) and Qingre Jiedu (QJ), are not clear. In this study, the efficacy of WYH and QJ on heart failure is evaluated by using transverse aortic constriction (TAC) induced mice and the significantly changed genes in heart tissues were screened with a DNA array. Furthermore, a new quantitative pathway analysis tool is developed to evaluate the differences of pathways in different groups and to identify the pharmacological contributions of the decomposed recipes. Finally, the related genes in the significantly changed pathways are verified by a real-time polymerase chain reaction and a Western blot. Our data show that both QJ and WYH improve the left ventricular ejection fraction, which explain their contributions to protect against heart failure. In the energy metabolism, QJ achieves the therapeutic effects of QSG through nicotinamide nucleotide transhydrogenase (Nnt)-mediated mechanisms. In ventricular remodeling and inflammation reactions, QJ and WYH undertake the therapeutic effects through 5-nucleotidase ecto (Nt5e)-mediated mechanisms. Together, QJ and WYH constitute the therapeutic effects of QSG and play important roles in myocardial energy metabolism and inflammation, which can exert therapeutic effects for heart failure. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS关键词 | CARDIAC-HYPERTROPHY ; EPIDEMIOLOGY ; METABOLISM ; MEDICINE ; FIBROSIS ; COMPLEX ; MODEL |
| 语种 | 英语 |
| WOS记录号 | WOS:000445301800332 |
| 出版者 | MDPI |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/851]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China; 2.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200032, Peoples R China; 4.Univ Chinese Acad Sci, Sch Life Sci, Beijing 100049, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ren, Weiquan,Zhang, Huimin,Ren, Yinglu,et al. Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method[J]. MOLECULES,2018,23(7):1829. |
| APA | Ren, Weiquan.,Zhang, Huimin.,Ren, Yinglu.,Yu, Xue.,Guo, Shuzhen.,...&,.(2018).Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method.MOLECULES,23(7),1829. |
| MLA | Ren, Weiquan,et al."Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method".MOLECULES 23.7(2018):1829. |
入库方式： OAI收割
来源：上海营养与健康研究所
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