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Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection

文献类型：期刊论文

作者Zhang, Xiaofei2,3; Yang, Gong1,2,3; Wang, Shuoer3; Wang, Shuoer1; Zhao, SongJiao4; Sun, Yidi5; ,
刊名CANCER MEDICINE
出版日期2018
卷号7期号:11页码:5488-5496
关键词chemotherapy ovarian cancer premenopausal women propensity score matching
ISSN号2045-7634
DOI10.1002/cam4.1822
文献子类Article
英文摘要Postoperative chemotherapy has been widely used in the treatment of early-staged ovarian cancer patients underwent unilateral resection, but the clinical decision mainly depends on the doctor's experience without a well-defined guideline. This study used propensity score matching to analyze the effect of postoperative chemotherapy for early-staged ovarian cancer patients underwent unilateral resection on prognosis. Patients of age 50 or younger than 50 with early-staged ovarian cancer were explored from the Surveillance, Epidemiology, and End Results program database during 2000-2018. Propensity score matching was used to randomize the dataset and reduce the selection biases. Univariate and multivariate cox proportional hazards models were utilized to estimate the necessity of chemotherapy. In univariate analysis of matched population, both the overall survival and cancer-specific survival analysis showed that chemotherapy had no effect on the prognosis of early-staged young ovarian cancer patients (Overall survival, P = 0.477; Cancer-specific survival, P = 0.950). In propensity-adjusted multivariate analysis, chemotherapy still had no effect on both the overall and cancer-specific survival probability after excluding the effect of all the confounding factors (HR = 0.863, CI = 0.587-1.269, P = 0.455; HR = 1.009, CI = 0.633-1.607, P = 0.970). Our study suggested that postoperative chemotherapy is not necessary for early-staged young ovarian cancer patients with unilateral resection, as indicated by both the overall survival and cancer-specific survival.
学科主题Oncology
语种英语
WOS记录号WOS:000450673300017
出版者WILEY
版本出版稿
源URL[http://202.127.25.144/handle/331004/853]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Fudan Univ, Peoples Hosp Shanghai 5, Cent Lab, Shanghai, Peoples R China;
2.Fudan Univ, Shanghai Canc Ctr, Canc Inst, Shanghai, Peoples R China;
3.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China;
4.Fudan Univ, Eye & ENT Hosp, Shanghai, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Zhang, Xiaofei,Yang, Gong,Wang, Shuoer,et al. Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection[J]. CANCER MEDICINE,2018,7(11):5488-5496.
APA Zhang, Xiaofei.,Yang, Gong.,Wang, Shuoer.,Wang, Shuoer.,Zhao, SongJiao.,...&,.(2018).Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection.CANCER MEDICINE,7(11),5488-5496.
MLA Zhang, Xiaofei,et al."Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection".CANCER MEDICINE 7.11(2018):5488-5496.

入库方式： OAI收割

来源：上海营养与健康研究所

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