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H3K14me3 genomic distributions and its regulation by KDM4 family demethylases

文献类型：期刊论文

作者Zhao, Bin8,9; Xu, Wenqi8,9; Rong, Bowen8,9; Ye, Xuanjia8,9; Dai, Ruofei8,9; Li, Wenjing8,9; Lan, Fei8,9; Chen, Guoyu10; Han, Jing-Dong J.10; Chen, Jiajia1,2
刊名CELL RESEARCH
出版日期2018
卷号28期号:11页码:1118-1120
关键词Multi-omic Tensor Dimensional reduction Independent component analysis mQTL Epigenome-wide association study Cancer
ISSN号1001-0602
DOI10.1038/s41422-018-0095-6
文献子类Letter
英文摘要There is an increased need for integrative analyses of multi-omic data. We present and benchmark a novel tensorial independent component analysis (tICA) algorithm against current state-of-the-art methods. We find that tICA outperforms competing methods in identifying biological sources of data variation at a reduced computational cost. On epigenetic data, tICA can identify methylation quantitative trait loci at high sensitivity. In the cancer context, tICA identifies gene modules whose expression variation across tumours is driven by copy-number or DNA methylation changes, but whose deregulation relative to normal tissue is independent of such alterations, a result we validate by direct analysis of individual data types.
学科主题Cell Biology
WOS关键词POSTTRANSLATIONAL MODIFICATIONS ; MASS-SPECTROMETRY ; CHROMATIN ; HISTONES
语种英语
WOS记录号WOS:000449267800010
出版者INST BIOCHEMISTRY & CELL BIOLOGY
版本出版稿
源URL[http://202.127.25.144/handle/331004/855]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Fudan Univ, Basic Med Coll, Inst Biomed Sci, Shanghai 20032, Peoples R China;
2.Fudan Univ, Dept Syst Biol Med, Shanghai 20032, Peoples R China;
3.Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China;
4.Jilin Univ, Hosp 1, Ctr Infect & Immun, Dept Resp Med, Changchun 130001, Jilin, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China;
6.Harvard Med Sch, Boston Childrens Hosp, Newborn Med Div, Boston, MA 02115 USA;
7.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA,
8.Fudan Univ, Key Lab Carcinogenesis & Canc Invas, Key Lab Epigenet & Metab, Liver Canc Inst,Zhongshan Hosp,Minist Educ,Minist, Shanghai 200032, Peoples R China;
9.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China;
10.Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev Biol, Max Planck Partner Inst Computat Biol,Shanghai In, Key Lab Computat Biol,CAS Ctr Excellence Mol Cell, 320 Yue Yang Rd, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Zhao, Bin,Xu, Wenqi,Rong, Bowen,et al. H3K14me3 genomic distributions and its regulation by KDM4 family demethylases[J]. CELL RESEARCH,2018,28(11):1118-1120.
APA Zhao, Bin.,Xu, Wenqi.,Rong, Bowen.,Ye, Xuanjia.,Dai, Ruofei.,...&,.(2018).H3K14me3 genomic distributions and its regulation by KDM4 family demethylases.CELL RESEARCH,28(11),1118-1120.
MLA Zhao, Bin,et al."H3K14me3 genomic distributions and its regulation by KDM4 family demethylases".CELL RESEARCH 28.11(2018):1118-1120.

入库方式： OAI收割

来源：上海营养与健康研究所

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