Gene expression across mammalian organ development
文献类型：期刊论文
| 作者 | Cardoso-Moreira, Margarida31,32; Ovchinnikova, Svetlana32; Anders, Simon32; Kaessmann, Henrik32; Halbert, Jean31; Valloton, Delphine31; Liechti, Angelica31; Ascencao, Kelly31; Rummel, Coralie31; Xenarios, Ioannis31 |
| 刊名 | NATURE
 |
| 出版日期 | 2019 |
| 卷号 | 571期号:7766页码:505-+ |
| ISSN号 | 0028-0836 |
| 关键词 | Histone demethylase Jmjd3 Myelopoiesis Spil Zebrafish |
| DOI | 10.1038/s41586-019-1338-5 |
| 文献子类 | Article |
| 英文摘要 | The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | BIOCONDUCTOR PACKAGE ; PHYLOTYPIC STAGE ; EVOLUTION ; TIME ; MECHANISMS ; PROFILES ; MASIGPRO ; RESOURCE ; VARIANTS ; ORIGINS |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000477016700059 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/860]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Newcastle Univ, Inst Genet Med, Human Dev Biol Resource, Newcastle, England; 2.Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA, 3.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China; 5.DZHK German Ctr Cardiovasc Res, Partner Site Gottingen, Gottingen, Germany; 6.Leibniz Inst Primate Res DPZ, German Primate Ctr, Platform Degenerat Dis, Gottingen, Germany; 7.Linkoping Univ, IFM Biol, AVIAN Behav Genom & Physiol Grp, Linkoping, Sweden; 8.Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Edinburg, TX USA; 9.Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Harlingen, TX USA; 10.Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX USA; |
| 推荐引用方式 GB/T 7714 | Cardoso-Moreira, Margarida,Ovchinnikova, Svetlana,Anders, Simon,et al. Gene expression across mammalian organ development[J]. NATURE,2019,571(7766):505-+. |
| APA | Cardoso-Moreira, Margarida.,Ovchinnikova, Svetlana.,Anders, Simon.,Kaessmann, Henrik.,Halbert, Jean.,...&,.(2019).Gene expression across mammalian organ development.NATURE,571(7766),505-+. |
| MLA | Cardoso-Moreira, Margarida,et al."Gene expression across mammalian organ development".NATURE 571.7766(2019):505-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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