Protective mechanisms of Qishen Granule on heart failure rats revealed by transcriptomic analysis
文献类型：期刊论文
| 作者 | Zhang, Jian2; Wang, Wei2; Lin, Weili1; Gao, Sheng4; Zhu, Ruixin4; Wang, Yong3; , |
| 刊名 | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 72期号:16页码:C29-C29 |
| ISSN号 | 0735-1097 |
| DOI | 10.1016/j.jacc.2018.08.109 |
| 文献子类 | Meeting Abstract |
| 英文摘要 | The explosive growth of high-throughput experimental methods and resulting data yields both opportunity and challenge for selecting the correct drug to treat both a specific patient and their individual disease. Ideally, it would be useful and efficient if computational approaches could be applied to help achieve optimal drug-patient-disease matching but current efforts have met with limited success. Current approaches have primarily utilized the measureable effect of a specific drug on target tissue or cell lines to identify the potential biological effect of such treatment. While these efforts have met with some level of success, there exists much opportunity for improvement. This specifically follows the observation that, for many diseases in light of actual patient response, there is increasing need for treatment with combinations of drugs rather than single drug therapies. Only a few previous studies have yielded computational approaches for predicting the synergy of drug combinations by analyzing high-throughput molecular datasets. However, these computational approaches focused on the characteristics of the drug itself, without fully accounting for disease factors. Here, we propose an algorithm to specifically predict synergistic effects of drug combinations on various diseases, by integrating the data characteristics of disease-related gene expression profiles with drug-treated gene expression profiles. We have demonstrated utility through its application to transcriptome data, including microarray and RNASeq data, and the drug-disease prediction results were validated using existing publications and drug databases. It is also applicable to other quantitative profiling data such as proteomics data. We also provide an interactive web interface to allow our Prediction of Drug-Disease method to be readily applied to user data. While our studies represent a preliminary exploration of this critical problem, we believe that the algorithm can provide the basis for further refinement towards addressing a large clinical need. |
| 学科主题 | Cardiovascular System & Cardiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000446586700104 |
| 出版者 | ELSEVIER SCIENCE INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/862]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Key Lab Computat Biol, Shanghai, Peoples R China; 2.Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China; 3.Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China, 4.Tongji Univ, Sch Life Sci & Technol, Dept Bioinformat, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Jian,Wang, Wei,Lin, Weili,et al. Protective mechanisms of Qishen Granule on heart failure rats revealed by transcriptomic analysis[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2018,72(16):C29-C29. |
| APA | Zhang, Jian.,Wang, Wei.,Lin, Weili.,Gao, Sheng.,Zhu, Ruixin.,...&,.(2018).Protective mechanisms of Qishen Granule on heart failure rats revealed by transcriptomic analysis.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,72(16),C29-C29. |
| MLA | Zhang, Jian,et al."Protective mechanisms of Qishen Granule on heart failure rats revealed by transcriptomic analysis".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 72.16(2018):C29-C29. |
入库方式： OAI收割
来源：上海营养与健康研究所
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