Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target
文献类型：期刊论文
| 作者 | Zhao, Huan5,7; He, Lingjuan5,7; Li, Yan5,7; Pu, Wenjuan5,7; Liu, Qiaozhen5,7; Tang, Juan5,7; Wu, Jiaying7; Cheng, Xin7; Zhou, Bin4,5,7,8; Tian, Xueying4 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 25期号:5页码:1241-+ |
| ISSN号 | 2211-1247 |
| 关键词 | prolyl hydroxylase intestinal epithelium homeostasis |
| DOI | 10.1016/j.celrep.2018.10.015 |
| 文献子类 | Article |
| 英文摘要 | Identification of cellular surface markers that distinguish tumorous from normal vasculature is important for the development of tumor vessel-targeted therapy. Here, we show that Apj, a G protein-coupled receptor, is highly enriched in tumor endothelial cells but absent from most endothelial cells of adult tissues in homeostasis. By genetic targeting using Apj-CreER and Apj-DTRGFP-Luciferase, we demonstrated that hypoxia-VEGF signaling drives expansion of Apj(+) tumor vessels and that targeting of these vessels, genetically and pharmacologically, remarkably inhibits tumor angiogenesis and restricts tumor growth. These in vivo findings implicate Apj(+) vessels as a key driver of pathological angiogenesis and identify Apj(+) endothelial cells as an important therapeutic target for the anti-angiogenic treatment of tumors. |
| 学科主题 | Cell Biology |
| WOS关键词 | PROTEIN-COUPLED RECEPTOR ; IN-VIVO ; APELIN-APJ ; ENDOTHELIAL-CELLS ; ANGIOGENIC FACTOR ; GENETIC ABLATION ; TRANSGENIC MICE ; TOXIN GENE ; T-CELLS ; EXPRESSION |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000448675900013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/863]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Dept Pediat Hematol Oncol, Xinhua Hosp, Shanghai 200092, Peoples R China; 2.ShanghaiTech Univ, IHuman Inst, Shanghai 201210, Peoples R China; 3.Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China; 4.Jinan Univ, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Guangdong, Peoples R China; 5.Univ Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Chinese Acad Sci, Shanghai 200031, Peoples R China; 6.Univ Oxford, British Heart Fdn Ctr Regenerat Med, Dept Physiol Anat & Genet, Oxford, England, 7.Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai 200031, Peoples R China; 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Huan,He, Lingjuan,Li, Yan,et al. Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target[J]. CELL REPORTS,2018,25(5):1241-+. |
| APA | Zhao, Huan.,He, Lingjuan.,Li, Yan.,Pu, Wenjuan.,Liu, Qiaozhen.,...&,.(2018).Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target.CELL REPORTS,25(5),1241-+. |
| MLA | Zhao, Huan,et al."Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target".CELL REPORTS 25.5(2018):1241-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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